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Acute kidney injury in 2014

A step towards understanding mechanisms of renal repair

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In 2014, key articles in the field of acute kidney injury highlighted the importance of tubular homeostasis in renal regeneration. Cell cycle regulators, inflammatory signals and progenitors were identified as important factors that mediate the balance between inflammation and tubular regeneration necessary for renal repair.

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Acknowledgements

A.B. is supported by a Center for Sepsis and Critical Illness Award P50 GM-111152 from the National Institute of General Medical Sciences.

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Authors and Affiliations

  1. Department of Anaesthesiology, University of Florida, 1600 SW Archer Road, Medical Science Building Room M526B, Gainesville, 32610, FL, USA

    Azra Bihorac

  2. Department of Critical Care Medicine, Center for Critical Care Nephrology, University of Pittsburgh, School of Medicine, Room 604 Scaife Hall, 3550 Terrace Street, Pittsburgh, 15261, PA, USA

    John A. Kellum

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  1. Azra Bihorac
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  2. John A. Kellum
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Correspondence to John A. Kellum.

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Competing interests

A.B. has received grant support from Astute Medical. J.A.K. has received grant support and consulting fees from Astute Medical and Baxter.

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Bihorac, A., Kellum, J. A step towards understanding mechanisms of renal repair. Nat Rev Nephrol 11, 74–75 (2015). https://doi.org/10.1038/nrneph.2014.245

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