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Chronic kidney disease

Arterial stiffness and renal function—a complex relationship

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New data suggest that aortic stiffness results in the transmission of excessive flow pulsatility to the renal microcirculation. Further understanding of the mechanisms that regulate the relationship between large arteries and the renal microcirculation could lead to new strategies to protect the kidneys from increased blood pressure load owing to systemic hypertension.

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References

  1. Blacher, J., Guerin, A. P., Pannier, B., Marchais, S. J. & London, G. M. Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease. Hypertension 38, 938–942 (2001).

    Article  CAS  Google Scholar 

  2. O'Rourke, M. F. & Safar, M. E. Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension 46, 200–204 (2005).

    Article  CAS  Google Scholar 

  3. Woodard, T. et al. Mediation analysis of aortic stiffness and renal microvascular function. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2014050450.

  4. Petersen, L. J. et al. The pulsatility index and the resistive index in renal arteries. Association with long-term progression in chronic renal failure. Nephrol. Dial. Transplant. 12, 1376–1380 (1997).

    Article  CAS  Google Scholar 

  5. Bardelli, M., Jensen, G., Volkmann, R., Caidhal, K. & Aurell, M. Experimental variation in renal vascular resistance in normal man as detected by means of ultrasound. Eur. J. Clin. Invest. 22, 619–624 (1992).

    Article  CAS  Google Scholar 

  6. Schillaci, G. et al. Relationship between short-term blood pressure variability and large-artery stiffness in human hypertension: findings from 2 large databases. Hypertension 60, 369–377 (2012).

    Article  CAS  Google Scholar 

  7. Parati, G., Ochoa, J. E. & Bilo, G. Blood pressure variability, cardiovascular risk, and risk for renal disease progression. Curr. Hypertens. Rep. 14, 421–431 (2012).

    Article  Google Scholar 

  8. Amann, K. Media calcification and intima calcification are distinct entities in chronic kidney disease. Clin. J. Am. Soc. Nephrol. 3, 1599–1605 (2008).

    Article  Google Scholar 

  9. Chue, C. D., Townend, J. N., Steeds, R. P. & Ferro, C. J. Arterial stiffness in chronic kidney disease: causes and consequences. Heart 96, 817–823 (2010).

    Article  Google Scholar 

  10. Salvi, P. Pulse waves. How Vascular Hemodynamics Affects Blood Pressure 17–44 (Springer, 2013).

    Google Scholar 

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Authors and Affiliations

  1. Istituto Auxologico Italiano, Laboratory of Cardiovascular Research, Piazza Brescia 20, Milan, 20149, Italy

    Paolo Salvi

  2. Istituto Auxologico Italiano and Department of Health Sciences, University of Milano-Bicocca, Piazza Brescia 20, Milan, 20149, Italy

    Gianfranco Parati

Authors
  1. Paolo Salvi
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  2. Gianfranco Parati
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Correspondence to Paolo Salvi.

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Competing interests

P.S. is a consultant for DiaTecne s.r.l., manufacturer of a pulse wave analysis system. G.P. declares no competing interests.

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Salvi, P., Parati, G. Arterial stiffness and renal function—a complex relationship. Nat Rev Nephrol 11, 11–13 (2015). https://doi.org/10.1038/nrneph.2014.226

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