A new population-based study of a Norwegian registry containing data on more than 5 million individuals has confirmed the existence of powerful familial clustering of complex aetiologies of end-stage renal disease. Novel strategies for identifying additional nephropathy risk genes will benefit from such large familial registries.
This is a preview of subscription content, log in via an institution to check access.
References
Skrunes, R., Svarstad, E., Reisaeter, A. V. & Vikse, B. E. Familial Clustering of ESRD in the Norwegian Population. Clin. J. Am. Soc. Nephrol. http://dx.doi.org/10.2215/CJN.01680214.
Seaquist, E. R., Goetz, F. C., Rich, S. & Barbosa, J. Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy. N. Engl. J. Med. 320, 1161–1165 (1989).
Maeda, S. et al. A single nucleotide polymorphism within the acetyl-coenzyme A carboxylase β gene is associated with proteinuria in patients with type 2 diabetes. PLoS Genet. 6, e1000842 (2010).
Pezzolesi, M. G. et al. Confirmation of genetic associations at ELMO1 in the GoKinD collection supports its role as a susceptibility gene in diabetic nephropathy. Diabetes 58, 2698–2702 (2009).
Genovese, G. et al. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 329, 841–845 (2010).
Freedman, B. I. et al. The Apolipoprotein L1 (APOL1) Gene and Nondiabetic Nephropathy in African Americans. J. Am. Soc. Nephrol. 21, 1422–1426 (2010).
Freedman, B. I. & Skorecki, K. Gene-Gene and Gene-Environment Interactions in Apolipoprotein L1 Gene-Associated Nephropathy. Clin. J. Am. Soc. Nephrol. http://dx.doi.org/10.2215/CJN.01330214.
Freedman, B. I., Spray, B. J., Tuttle, A. B. & Buckalew, V. M. Jr., The familial risk of end-stage renal disease in African Americans. Am. J. Kidney Dis. 21, 387–393 (1993).
Santin, S. et al. Clinical utility of genetic testing in children and adults with steroid-resistant nephrotic syndrome. Clin. J. Am. Soc. Nephrol. 6, 1139–1148 (2011).
Bleyer, A. J., Hart, P. S. & Kmoch, S. Hereditary interstitial kidney disease. Semin. Nephrol. 30, 366–373 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Freedman, B., Robinson, T. Familial aggregation of ESRD in Europeans—is it in the genes?. Nat Rev Nephrol 10, 677–678 (2014). https://doi.org/10.1038/nrneph.2014.181
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2014.181
- Springer Nature Limited
This article is cited by
-
A single nucleotide polymorphism in the UMOD promoter is associated with end stage renal disease
BMC Medical Genetics (2016)