Skip to main content

Advertisement

SpringerLink
Log in

Glomerular disease

Limiting autoimmune tissue injury: ROS and the inflammasome

  • News & Views
  • Published:

From Nature Reviews Nephrology

View current issue Sign up to alerts

Schreiber et al. have identified an unexpected immunoregulatory role of reactive oxygen species in antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis. Here, we discuss these findings in view of other pathways with well-known immunostimulatory roles in kidney disease that have recently been shown to have additional immunosuppressive effects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Immunoregulatory roles of ROS, NLRP3 and ASC.

References

  1. de Zeeuw, D. et al. Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease. N. Engl. J. Med. 369, 2492–2503 (2013).

    Article  CAS  Google Scholar 

  2. Schreiber, A., Luft, F. C. & Kettritz, R. Phagocyte NADPH oxidase restrains the inflammasome in ANCA-induced GN. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2013111177.

  3. Schroder, K. & Tschopp, J. The inflammasomes. Cell 140, 821–832 (2010).

    Article  CAS  Google Scholar 

  4. Zhou, R., Tardivel, A., Thorens, B., Choi, I. & Tschopp, J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 11, 136–140 (2010).

    Article  CAS  Google Scholar 

  5. Lichtnekert, J. et al. Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1. PLoS ONE 6, e26778 (2011).

    Article  CAS  Google Scholar 

  6. Kayagaki, N. et al. Non-canonical inflammasome activation targets caspase-11. Nature 479, 117–121 (2011).

    Article  CAS  Google Scholar 

  7. Lech, M. et al. NLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-β receptor signalling. Ann. Rheum. Dis. (http://dx.doi.org/10.1136/annrheumdis-2014-205496).

  8. Kulkarni, O. P. et al. Toll-like receptor 4-induced IL-22 accelerates kidney regeneration. J. Am. Soc. Nephrol. 25, 978–989 (2014).

    Article  CAS  Google Scholar 

  9. Schauer, C. et al. Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. Nat. Med. 20, 511–517 (2014).

    Article  CAS  Google Scholar 

  10. Weidenbusch, M. & Anders, H. J. Tissue microenvironments define and get reinforced by macrophage phenotypes in homeostasis or during inflammation, repair and fibrosis. J. Innate Immun. 4, 463–477 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Nephrology, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ziemssenstraße 1, Munich, D-80336, Germany

    Santhosh V. R. Kumar & Hans-Joachim Anders

Authors
  1. Santhosh V. R. Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hans-Joachim Anders
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hans-Joachim Anders.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kumar, S., Anders, HJ. Limiting autoimmune tissue injury: ROS and the inflammasome. Nat Rev Nephrol 10, 545–546 (2014). https://doi.org/10.1038/nrneph.2014.156

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2014.156

  • Springer Nature Limited

This article is cited by

Search

Navigation