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Transplantation

Donor-specific HLA antibodies and renal allograft failure

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A new meta-analysis shows a strong association between low levels of preformed donor-specific HLA antibodies (DSAs) detected using sensitive solid-phase assays and an increased risk of renal allograft failure. These findings have important implications for stratifying patients with DSAs for organ allocation and for the use of alloantigen desensitization therapies.

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Acknowledgements

We would like to acknowledge the support of the Paris Cardiovascular Research Centre University Paris, Descartes and the Transplant Immunotherapy Program and HLA Laboratory at Cedars-Sinai Medical Center.

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Authors and Affiliations

  1. Department of Kidney Transplantation, Necker Hospital, UMR-S970, 75014, Paris, France

    Alexandre Loupy

  2. Comprehensive Transplant Center, Kidney Transplant Program and Transplant Immunotherapy Program, Cedars–Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, 90048, CA, USA

    Stanley C. Jordan

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  1. Alexandre Loupy
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  2. Stanley C. Jordan
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Correspondence to Stanley C. Jordan.

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The authors declare no competing financial interests.

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Loupy, A., Jordan, S. Donor-specific HLA antibodies and renal allograft failure. Nat Rev Nephrol 9, 130–131 (2013). https://doi.org/10.1038/nrneph.2013.18

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