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Pediatric nephrology

Estimating GFR in children: Schwartz redux

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One of the early products of the Chronic Kidney Disease in Children (CKiD) study has been an updated equation for estimating GFR in children on the basis of demographic and laboratory parameters. This formula is comparable in form and performance to the MDRD equations for adults in clinical trials first published a decade ago.

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References

  1. Schwartz, G. J., Haycock, G. B., Edelmann, C. M. & Spitzer, A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 58, 259–263 (1976).

    CAS  PubMed  Google Scholar 

  2. Cockcroft, D. W. & Gault, M. H. Prediction of creatinine clearance from serum creatinine. Nephron 16, 31–41 (1976).

    Article  CAS  Google Scholar 

  3. Levey, A. S. et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann. Int. Med. 130, 461–470 (1999).

    Article  CAS  Google Scholar 

  4. Schwartz, G. J. et al. New equations to estimate GFR in children with CKD. J. Am. Soc. Nephrol. 20, 629–637 (2009).

    Article  Google Scholar 

  5. Schwartz, G. J., Furth, S., Cole, S. R., Warady, B. & Muñoz, A. Glomerular filtration rate via plasma iohexol disappearance: pilot study for chronic kidney disease in children. Kidney Int. 69, 2070–2077 (2006).

    Article  CAS  Google Scholar 

  6. Schwartz, G. J. & Furth, S. L. Glomerular filtration rate measurement and estimation in chronic kidney disease. Pediatr. Nephrol. 22, 1839–1848 (2007).

    Article  Google Scholar 

  7. Sterner, G. et al. Determining 'true' glomerular filtration rate in healthy adults using infusion of inulin and comparing it with values obtained using other clearance techniques or prediction equations. Scand. J. Urol. Nephrol. 42, 278–285 (2008).

    Article  CAS  Google Scholar 

  8. Pierrat, A. et al. Predicting GFR in children and adults: a comparison of the Cockcroft-Gault, Schwartz, and Modification of Diet in Renal Disease formulas. Kidney Int. 64, 1425–1436 (2003).

    Article  Google Scholar 

  9. US Food and Drug Administration. The Preliminary Concept Paper: Pharmacokinetics in Patients with Impaired Renal Function—Study Design, Data Analysis, and Impact on Dosing and Labeling http://www.fda.gov/ohrms/dockets/ac/08/briefing/2008-4351b1-00-index.htm 57–73 (2008).

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  1. K. V. Lemley, Division of Nephrology, MS#40, Childrens Hospital Los Angeles, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA klemley@chla.usc.edu

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  1. Childrens Hospital Los Angeles, CA, USA

    Kevin V. Lemley

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  1. Kevin V. Lemley
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Lemley, K. Estimating GFR in children: Schwartz redux. Nat Rev Nephrol 5, 310–311 (2009). https://doi.org/10.1038/nrneph.2009.56

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