Skip to main content

Advertisement

Log in

Transplantation

Supplemental vitamin D: will do no harm and might do good

  • News & Views
  • Published:

From Nature Reviews Nephrology

View current issue Sign up to alerts

Vitamin D insufficiency is endemic amongst renal transplant recipients, as it is in other individuals with chronic diseases, both within and beyond nephrology. Few data exist to guide vitamin D replacement strategies, but indirect evidence points to likely skeletal, and possibly extraskeletal, benefits from supplementation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: The metabolism of vitamin D.

References

  1. Jones, R. The Cripples' Journal Vol. 1, No. 1 Published by The Shropshire Orthopaedic Hospital, Oswestry, England (1924).

    Google Scholar 

  2. Holick, M. F. Resurrection of vitamin D deficiency and rickets. J. Clin. Invest. 116, 2062–2072 (2006).

    Article  CAS  Google Scholar 

  3. Cunningham, J. Post-transplantation bone disease. Transplantation 79, 629–634 (2005).

    Article  Google Scholar 

  4. Palmer, S. C. et al. Interventions for preventing bone disease in kidney transplant recipients. Cochrane Database of Systematic Reviews, Issue 2. Art. No.:CD005015 doi:10.1002/14651858.CD005015.pub3 (2007).

  5. Saito, H. et al. Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1α,25-dihydroxyvitamin D3 production. J. Biol. Chem. 278, 2206–2211 (2003).

    Article  CAS  Google Scholar 

  6. Courbebaisse, M. et al. Effects of vitamin D supplementation on the calcium–phosphate balance in renal transplant patients. Kidney Int. 75, 646–651 (2009).

    Article  CAS  Google Scholar 

  7. Heaney, R. P. Serum 25-hydroxy-vitamin D and the health of the calcium economy. In Nutritional Aspects of Osteoporosis, 2nd edn (eds Burckhardt, P. et al.) 227–244 (San Diego, Elsevier, 2004).

  8. Hathcock, J. N. Risk assessment for vitamin D. Am. J. Clin. Nutr. 85, 6–18 (2007).

    Article  CAS  Google Scholar 

  9. London, G. M. et al. Mineral metabolism and arterial functions in end-stage renal disease: potential role of 25-hydroxyvitamin D deficiency. J. Am. Soc. Nephrol. 18, 613–620 (2007).

    Article  CAS  Google Scholar 

  10. Walsh, S. B. et al. Effect of pamidronate on bone loss after kidney transplantation: a randomized trial. Am. J. Kidney Dis. 53, 856–865 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John Cunningham.

Ethics declarations

Competing interests

The author declares associations with the following companies: Cytochroma (consultant) and Abbott (speakers bureau—honoraria).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cunningham, J. Supplemental vitamin D: will do no harm and might do good. Nat Rev Nephrol 5, 614–615 (2009). https://doi.org/10.1038/nrneph.2009.143

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2009.143

  • Springer Nature Limited

This article is cited by

Navigation