Abstract
George Palade has created, shared and passed on a multidisciplinary view of the functional organization, biogenesis and dynamics of organelles. His open-mindedness and tenacity, along with his rigour and sense of intellectual elegance, have been remarkable. This focus on the logic of organelles defined a crucial turning point in biomedical science. The following article sketches Palade's research, as part of a larger community that flourished after the Second World War.
References
Porter, K. An informal tribute to George E. Palade. J. Cell Biol. 97, D4–D7 (1983).
Sabatini, D. George E. Palade: charting the secretory pathway. Trends Cell Biol. 9, 413–417 (1999).
ASCB Profile of George Palade. ASCB Newslett. 23, 8–10 (2000).
Claude, A. The coming of age of the cell. Science 189, 433–435 (1975).
Palade, G. E. Albert Claude and the beginnings of biological electron microscopy. J. Cell Biol. 50, 5D–19D (1971).
Claude, A. Studies on cells: morphology, chemical constitution, and distribution of biochemical functions. Harvey Lect. 43, 121–164 (1948).
Porter, K. R. George Hall Hogeboom (1913–1956). J. Biophys. Biochem. Cytol. 2, ix–xvi (1956).
de Duve, C. Exploring cells with a centrifuge. Science 189, 186–194 (1975).
Lehninger, A. L. The Mitochondrion; Molecular Basis of Structure and Function (W. A. Benjamin, New York, 1964).
Ernster, L. & Schatz, G. E. Mitochondria: a historical review. J. Cell Biol. 91, 227s–255s (1981).
Palade, G. E. Keith Roberts Porter and the development of contemporary cell biology. J. Cell Biol. 75, D3–D18 (1977).
Pease, D. C. & Porter, K. R. Electron microscopy. J. Cell Biol. 91, 287s–292s (1981).
Siekevitz, P. & Zamecnik, P. Ribosomes and protein synthesis. J. Cell Biol. 91, 53s–65s (1981).
Palade, G. E. Intracellular aspects of the process of protein secretion. Science 189, 347–358 (1975).
Scheele, G. Pancreatic lobules in the in vitro study of pancreatic acinar cell function. Methods Enzymol. 98, 17–28 (1983).
Blobel, G. Protein targeting. Chembiochem. 1, 86–102 (2000).
Palade, G. E. in Symposium on Membrane Recycling (eds Evered, D. & Collins, G.) 1–14 (Ciba Foundation Symp. 92, Pitman Press, Bath, UK, 1982).
Porter, K. R. & Bennett, H. Stanley. Recollections on the beginning of the Journal of Cell Biology. J. Cell Biol. 91 (Suppl.), vii–ix (1981).
Palade, G. E. The American academia and the private sector. Kos 95–96, 23–28 (1993).
Palade, G. E. in Transport of Macromolecules in Cellular Systems (ed. Silverstein, S. C.) 517–522 (Dahlem Konferenzen, Berlin, 1978).
Hanson, E. Achievements: A Century of Science for the Benefit of Humankind. 1901–2001 (Rockefeller Univ. Press, New York, 2000).
Dallner, G., Siekevitz, P. & Palade, G. Biogenesis of endoplasmic reticulum membranes. J. Cell Biol. 30, 73–96 (1966).
Simionescu, N., Simionescu, M. & Palade, G. Differentiated microdomains on the luminal surface of the capillary endothelium. J. Cell Biol. 90, 605–613 (1981).
Wilson, E. B. The Cell in Development and Heredity (Macmillan, New York, 1896).
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Tartakoff, A. George Emil Palade: charismatic virtuoso of cell biology. Nat Rev Mol Cell Biol 3, 871–876 (2002). https://doi.org/10.1038/nrm953
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DOI: https://doi.org/10.1038/nrm953
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Correction: George Emil Palade: charismatic virtuoso of cell biology
Nature Reviews Molecular Cell Biology (2003)