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Mapping the 3D genome: Aiming for consilience

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Abstract

The spatial organization of genomes is studied using microscopy- and chromosome conformation capture (3C)-based methods. The two types of methods produce data that are often consistent, but there are cases where they appear discordant. These cases provide opportunities to derive better models of chromatin folding, which can reconcile the datasets.

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Figure 1: Measuring the distributions of distances between two pairs of loci in a cell population.

References

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Acknowledgements

The author thanks G. Fudenberg, M. Imakaev, L. Mirny and members of the Dekker laboratory for discussions and sharing insights.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Pharmacology, Howard Hughes Medical Institute, Program in Systems Biology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, 01605-0103, Massachusetts, USA

    Job Dekker

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  1. Job Dekker
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Correspondence to Job Dekker.

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Dekker, J. Mapping the 3D genome: Aiming for consilience. Nat Rev Mol Cell Biol 17, 741–742 (2016). https://doi.org/10.1038/nrm.2016.151

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