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Can primary immunodeficiencies help to provide insights into infectious risks of therapeutic antibodies?

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Abstract

Patients treated with monoclonal antibodies directed against immunological molecules may be viewed as being similar to patients with primary immunodeficiency (PID) of the corresponding antibody target, with regards to infectious risk. László Maródi and Jean-Laurent Casanova propose that the natural history of PIDs might indicate which infectious diseases should be monitored in patients receiving therapeutic antibodies.

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Author information

Authors and Affiliations

  1. László Maródi is at the Department of Infectious and Pediatric Immunology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary.,

    László Maródi

  2. Jean-Laurent Casanova is at the Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University Hospital, The Rockefeller University, New York, New York, USA, and Necker Branch, Paris Descartes University, Necker Medical School, Paris, France. lmarodi@dote.hu; jean-laurent.casanova@rockefeller.edu,

    Jean-Laurent Casanova

  3. jean-laurent.casanova@rockefeller.edu,

    Jean-Laurent Casanova

Authors
  1. László Maródi
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  2. Jean-Laurent Casanova
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The authors declare no competing financial interests.

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Maródi, L., Casanova, JL. Can primary immunodeficiencies help to provide insights into infectious risks of therapeutic antibodies?. Nat Rev Immunol 10, 299–300 (2010). https://doi.org/10.1038/nri2764

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