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Women and alcoholic liver disease — warning of a silent danger

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Alcohol use and 'social' drinking are increasing among the young and particularly in women. However, gender equity does not extend to the risk of alcohol-associated liver disease and alcoholic hepatitis, which are increased and often caused by as little as half as much cumulative alcohol consumption in women compared with men.

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Figure 1: Factors contributing to increased risk of alcohol-associated liver disease in women.

References

  1. Louvet, A. & Mathurin, P. Alcoholic liver disease: mechanisms of injury and targeted treatment. Nat. Rev. Gastroenterol. Hepatol. 12, 231–242 (2015).

    Article  PubMed  Google Scholar 

  2. Wilkinson, P., Kornaczewski, A., Rankin, J. G. & Santamaria, J. N. Physical disease in alcoholism. Initial survey of 1,000 patients. Med. J. Aust. 1, 1217–1223 (1971).

    Article  CAS  PubMed  Google Scholar 

  3. Saunders, J. B., Davis, M. & Williams, R. Do women develop alcoholic liver disease more readily than men? Br. Med. J. 282, 1140–1143 (1981).

    Article  CAS  Google Scholar 

  4. Yamauchi, M. Alcoholic liver disease in women. Japan Med. Associ. J. 45, 111–117 (2002).

    Google Scholar 

  5. Shimizu, I., Kamochi, M., Yoshikawa, H. & Nakayama, N. in Trends in Alcoholic Liver Disease Research — Clinical and Scientific Aspects (ed. Shimizu, I.) Ch. 2 (InTech, 2012).

    Book  Google Scholar 

  6. Spain, D. M. Portal cirrhosis of the liver. A review of two hundred fifty necropsies with references to sex differences. Am. J. Clin. Pathol. 15, 215–218 (1945).

    Article  Google Scholar 

  7. Szabo, G. & Petrasek, J. Gut-liver axis and sterile signals in the development of alcoholic liver disease. Alcohol Alcohol. 52, 414–424 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Bala, S., Marcos, M., Gattu, A., Catalano, D. & Szabo, G. Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals. PLoS ONE 9, e96864 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Ikejima, K. et al. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. Am. J. Physiol. 274, G669–676 (1998).

    CAS  PubMed  Google Scholar 

  10. Colantoni, A., Emanuele, M. A., Kovacs, E. J., Villa, E. & Van Thiel, D. H. Hepatic estrogen receptors and alcohol intake. Mol. Cell Endocrinol. 193, 101–104 (2002).

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Gyongyi Szabo.

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Szabo, G. Women and alcoholic liver disease — warning of a silent danger. Nat Rev Gastroenterol Hepatol 15, 253–254 (2018). https://doi.org/10.1038/nrgastro.2018.8

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