A new genome-wide association study (GWAS) has been conducted to discover genetic contributions that can explain disease prognosis in Crohn's disease. This understudied area deserves attention for discovering genetic variants responsible for disease severity, as well as encouraging scientists to analyse or reanalyse GWAS data using various clinically important endophenotypes.
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References
Liu, J. Z. et al. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat. Genet. 47, 979–986 (2015).
Rieder, F., Zimmermann, E. M., Remzi, F. H. & Sandborn, W. J. Crohn's disease complicated by strictures: a systematic review. Gut 62, 1072–1084 (2013).
Dubinsky, M. C. et al. Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease. Inflamm. Bowel Dis. 19, 1662–1670 (2013).
Kaur, M. et al. Perianal Crohn's disease is associated with distal colonic disease, stricturing disease behavior, IBD-associated serologies and genetic variation in the JAK-STAT pathway. Inflamm. Bowel Dis. 22, 862–869 (2016).
Helio, T. et al. CARD15/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn's disease. Gut 52, 558–562 (2003).
Cleynen, I. et al. Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study. Lancet 387, 156–167 (2016).
Satsangi, J., Grootscholten, C., Holt, H. & Jewell, D. P. Clinical patterns of familial inflammatory bowel disease. Gut 38, 738–741 (1996).
Lee, J. C. et al. Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. Nat. Genet. 49, 262–268 (2017).
de Lange, K. M. et al. Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. Nat. Genet. 49, 256–261 (2017).
Luo, Y. et al. Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7. Nat. Genet. 49, 186–192 (2017).
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Mondal, K., Kugathasan, S. Genetic differences in Crohn's disease susceptibility and outcome. Nat Rev Gastroenterol Hepatol 14, 266–268 (2017). https://doi.org/10.1038/nrgastro.2017.24
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DOI: https://doi.org/10.1038/nrgastro.2017.24
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