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Gut microbiota

Microbes offer engineering strategies to combat cancer

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This commentary outlines our expanding opportunities to harness the gut microbiota for cancer prevention and remission. Ultimately, simple microbial strategies might impart immune balance throughout the body leading to sustained good health.

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Figure 1: Microbe exposures stimulate the immune system against cancer.

References

  1. Maynard, C. L., Elson, C. O., Hatton, R. D. & Weaver, C. T. Reciprocal interactions of the intestinal microbiota and immune system. Nature 489, 231–241 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Erdman, S. E. et al. Unifying roles for regulatory T cells and inflammation in cancer. Int J. Cancer 126, 1651–1665 (2010).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Troy, E. B. & Kasper, D. L. Beneficial effects of Bacteroides fragilis polysaccharides on the immune system. Front. Biosci. (Landmark Ed.) 15, 25–34 (2010).

    Article  CAS  Google Scholar 

  4. Bissell, M. J. & Radisky, D. Putting tumours in context. Nat. Rev. Cancer 1, 46–54 (2001).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Rao, V. P., Poutahidis, T., Fox, J. G. & Erdman, S. E. Breast cancer: should gastrointestinal bacteria be on our radar screen? Cancer Res. 67, 847–850 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. Erdman, S. E. & Poutahidis, T. Gut bacteria and cancer. Biochim Biophys Acta 1856, 86–90 (2015).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Dinan, T. G., Stanton, C. & Cryan, J. F. Psychobiotics: a novel class of psychotropic. Biol. Psychiatry 74, 720–726 (2013).

    Article  CAS  PubMed  Google Scholar 

  8. Vetizou, M. et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 350, 1079–1084 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Wu, S. et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat. Med. 15, 1016–1022 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Poutahidis, T. et al. Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin. PLoS ONE 8, e78898 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Susan E. Erdman.

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Erdman, S. Microbes offer engineering strategies to combat cancer. Nat Rev Gastroenterol Hepatol 13, 125–126 (2016). https://doi.org/10.1038/nrgastro.2016.14

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  • DOI: https://doi.org/10.1038/nrgastro.2016.14

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