Obesity is a risk factor for several noncommunicable diseases, but some individuals with obesity remain metabolically healthy throughout life; whether these individuals are at risk of developing NAFLD is uncertain. In a new study, Chang et al. showed a statistically significant, graded relationship between BMI and NAFLD in metabolically healthy individuals.
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References
Chang, Y. et al. Metabolically healthy obesity and the development of nonalcoholic fatty liver disease. Am. J. Gastroenterol. http://dx.doi.org/10.1038/ajg.2016.178 (2016).
Bergman, R. N. et al. Abdominal obesity: role in the pathophysiology of metabolic disease and cardiovascular risk. Am. J. Med. 120, S3–S8 (2007).
Kramer, C. K., Zinman, B. & Retnakaran, R. Are metabolically healthy overweight and obesity benign conditions?: A systematic review and meta-analysis. Ann. Intern. Med. 159, 758–769 (2013).
Roberson, L. L. et al. Beyond BMI: the 'metabolically healthy obese' phenotype and its association with clinical/subclinical cardiovascular disease and all-cause mortality — a systematic review. BMC. Public Health 14, 14 (2014).
Ortega, F. B. et al. The intriguing metabolically healthy but obese phenotype: cardiovascular prognosis and role of fitness. Eur. Heart. J. 34, 389–397 (2013).
Stefan, N. et al. Identification and characterization of metabolically benign obesity in humans. Arch. Intern. Med. 168, 1609–1616 (2008).
Byrne, C. D. & Targher, G. NAFLD: a multisystem disease. J. Hepatol. 62, S47–S64 (2015).
Sung, K. C., Cha, S. C., Sung, J. W., So, M. S. & Byrne, C. D. Metabolically healthy obese subjects are at risk of fatty liver but not pre-clinical atherosclerosis. Nutr. Metab. Cardiovasc. Dis. 24, 256–262 (2014).
Aune, D. et al. Body mass index and all-cause mortality: a systematic review and nonlinear dose-response meta-analysis of 230 prospective studies with 3.74 million deaths among 30.3 million participants. BMJ 353, i2156 (2016).
Afzal, S., Tybjærg-Hansen, A., Jensen, G. B. & Nordestgaard, B. G. Change in body mass index associated with lowest mortality in Denmark, 1976–2013. JAMA 315, 1989–1996 (2016).
Acknowledgements
G.T. is supported in part by grants from the University School of Medicine of Verona, Verona, Italy. C.D.B. is supported in part by the Southampton National Institute for Health Research Biomedical Research Centre.
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Targher, G., Byrne, C. Metabolically healthy obesity and NAFLD. Nat Rev Gastroenterol Hepatol 13, 442–444 (2016). https://doi.org/10.1038/nrgastro.2016.104
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DOI: https://doi.org/10.1038/nrgastro.2016.104
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