Functional gastrointestinal disorders (FGIDs) have traditionally been diagnosed on the basis of characteristic symptom patterns in the absence of organic disease that explains the symptoms. Evidence is now emerging that structural abnormalities in the brain might have a role in the pathophysiology of FGIDs.
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References
Zhou, G. et al. White-matter microstructural changes in functional dyspepsia: a diffusion tensor imaging study. Am. J. Gastroenterol. 108, 260–269 (2013).
Mayer, E. A. & Tillisch, K. The brain–gut axis in abdominal pain syndromes. Annu. Rev. Med. 62, 381–396 (2011).
Van Oudenhove, L. & Aziz, Q. The role of psychosocial factors and psychiatric disorders in functional dyspepsia. Nat. Rev. Gastroenterol. Hepatol. 10, 158–167 (2013).
Tillisch, K. & Labus, J. S. Advances in imaging the brain–gut axis: functional gastrointestinal disorders. Gastroenterology 140, 407–411 (2011).
Ladabaum, U., Roberts, T. P. & McGonigle, D. J. Gastric fundic distension activates fronto-limbic structures but not primary somatosensory cortex: a functional magnetic resonance imaging study. Neuroimage 34, 724–732 (2007).
Larsson, M. B. et al. Brain responses to visceral stimuli reflect visceral sensitivity thresholds in patients with irritable bowel syndrome. Gastroenterology 142, 463–472 (2012).
Chen, J. Y., Blankstein, U., Diamant, N. E. & Davis, K. D. White matter abnormalities in irritable bowel syndrome and relation to individual factors. Brain Res. 1392, 121–131 (2011).
Seminowicz, D. A. et al. Regional gray matter density changes in brains of patients with irritable bowel syndrome. Gastroenterology 139, 48–57 (2010).
Basser, P. J., Mattiello, J. & LeBihan, D. Estimation of the effective self-diffusion tensor from the NMR spin echo. J. Magn. Reson. B 103, 247–254 (1994).
Ellingson, B. M. et al. Diffusion tensor imaging (DTI) detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome (IBS). Pain (in press).
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Mayer, E., Tillisch, K. & Ellingson, B. Structural changes in functional gastrointestinal disorders. Nat Rev Gastroenterol Hepatol 10, 200–202 (2013). https://doi.org/10.1038/nrgastro.2013.39
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DOI: https://doi.org/10.1038/nrgastro.2013.39
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