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Liver fibrosis in 2012

Convergent pathways that cause hepatic fibrosis in NASH

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Efforts to understand fatty liver disease have focused on the gut microbiome's stimulation of hepatic injury and fibrosis through specialized signalling complexes at the cell surface and in the cytosol of liver cells. Combined with increased hedgehog activity and progenitor cell expansion, new clues are emerging to elucidate the pathogenesis of fibrosis.

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Figure 1: Emerging pathways of fibrogenesis in fatty liver disease.

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Acknowledgements

S. L. Friedman receives funding from the National Institutes of Health (DK56621 and AA020709).

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  1. Mount Sinai School of Medicine, Box 1123, 1425 Madison Avenue, Room 11-70C, New York, 10029-6574, NY, USA

    Scott L. Friedman

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  1. Scott L. Friedman
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The author declares no competing financial interests.

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Friedman, S. Convergent pathways that cause hepatic fibrosis in NASH. Nat Rev Gastroenterol Hepatol 10, 71–72 (2013). https://doi.org/10.1038/nrgastro.2012.256

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