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Gut microbiota

Diet promotes dysbiosis and colitis in susceptible hosts

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New findings demonstrate novel interactions between diet, bacteria, genetic susceptibility and immune responses in IBD. Milk fat increases production of taurocholine-conjugated bile acids, which promotes growth of sulphate-reducing bacteria that cause immune-mediated colitis in susceptible mice. These observations will guide human studies that might improve dietary advice for patients with IBD.

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Figure 1: Diet promotes dysbiosis and colitis in susceptible hosts.

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Authors and Affiliations

  1. Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, CB #7032, Room 7039, Biomolecular Building, Chapel Hill, 27599-7032, NC, USA

    R. Balfour Sartor

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  1. R. Balfour Sartor
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The author declares no competing financial interests.

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Sartor, R. Diet promotes dysbiosis and colitis in susceptible hosts. Nat Rev Gastroenterol Hepatol 9, 561–562 (2012). https://doi.org/10.1038/nrgastro.2012.157

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