Hyperplastic polyposis syndrome is a widely accepted, but poorly understood, risk factor for colorectal cancer. A recent report has laid the foundations for improving the management of patients with this enigmatic disorder by identifying the features associated with colorectal cancer risk, as well as estimating the magnitude of this risk.
References
East, J. E., Saunders, B. P. & Jass, J. R. Sporadic and syndromic hyperplastic polyps and serrated adenomas of the colon: classification, molecular genetics, natural history, and clinical management. Gastroenterol. Clin. North Am. 37, 25–46 (2008).
Boparai, K. S. et al. Increased colorectal cancer risk during follow-up in patients with hyperplastic polyposis syndrome: a multicentre cohort study. Gut 59, 1094–1100 (2010).
Rashid, A. et al. Phenotypic and molecular characteristics of hyperplastic polyposis. Gastroenterology 119, 323–332 (2000).
Torlakovic, E. & Snover, D. C. Serrated adenomatous polyposis in humans. Gastroenterology 110, 748–755 (1996).
Buchanan, D. D. et al. Phenotypic diversity in patients with multiple serrated polyps: a genetics clinic study. Int. J. Colorectal Dis. 25, 703–712 (2010).
Buchanan, D. D. et al. Risk factors for colorectal cancer in patients with multiple serrated polyps: a cross-sectional case series from genetics clinics. PLoS ONE 5, e11636 (2010).
Burt, R. & Jass, J. R. in Pathology and Genetics of Tumours of the Digestive System (eds Hamilton, S. R. & Aaltonen, L. A.) 135–136 (IARC Press, Lyon, 2000).
Carvajal-Carmona, L. G. et al. Molecular classification and genetic pathways in hyperplastic polyposis syndrome. J. Pathol. 212, 378–385 (2007).
Chow, E. et al. Hyperplastic polyposis syndrome: phenotypic presentations and the role of MBD4 and MYH. Gastroenterology 131, 30–39 (2006).
Lynch, P. M. Hyperplastic polyposis: semantics, biology, and endoscopy. Gut 59, 1019–1021 (2010).
Acknowledgements
Joanne Young is supported by a Cancer Council Queensland Senior Research Fellowship and by a grant from the National Cancer Institute 1R01CA123010 (Genetics of Serrated Neoplasia).
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Young, J., Parry, S. Hyperplastic polyposis syndrome and risk of colorectal cancer. Nat Rev Gastroenterol Hepatol 7, 594–595 (2010). https://doi.org/10.1038/nrgastro.2010.166
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DOI: https://doi.org/10.1038/nrgastro.2010.166
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