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Does bariatric surgery reduce the severity of NAFLD?

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A long-term follow-up study used sequential liver biopsy specimens to evaluate fibrosis and signs of steatohepatitis in a large number of severely obese patients undergoing bariatric surgery, and found that bariatric surgery reduces steatosis in most patients. There are some important lessons to be learnt from the findings of this study and some unanswered questions for further investigation.

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References

  1. Clark, J. M. The epidemiology of nonalcoholic fatty liver disease in adults. J. Clin. Gastroenterol. 40 (Suppl. 1), S5–S10 (2006).

    PubMed  Google Scholar 

  2. Baker, M. K., Byrne, T. K. & Feldmann, M. E. Surgical treatment of obesity. Prim. Care 36, 417–427 (2009).

    Article  Google Scholar 

  3. Mathurin, P. et al. prospective study of long-term effects of bariatric surgery on liver injury in patients without advanced disease. Gastroenterology 137, 532–540 (2009).

    Article  CAS  Google Scholar 

  4. Mummadi, R. R., Kasturi, K. S., Chennareddygari, S. & Sood, G. K. Effect of bariatric surgery on nonalcoholic fatty liver disease: systematic review and meta-analysis. Clin. Gastroenterol. Hepatol. 6, 1396–1402 (2008).

    Article  Google Scholar 

  5. de Andrade, A. R. et al. Nonalcoholic fatty liver disease in severely obese individuals: the influence of bariatric surgery. Ann. Hepatol. 4, 364–368 (2008).

    Google Scholar 

  6. Dixon, J. B., Bhathal, P. S., Hughes, N. R. & O'Brien, P. E. Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss. Hepatology 39, 1647–1654 (2004).

    Article  Google Scholar 

  7. Brunt, E. M. et al. Portal chronic inflammation in nonalcoholic fatty liver disease (NAFDL): a histologic marker of advanced NAFLD-clinicopathologic correlations from the Nonalcoholic Steatohepatitis Clinical Research Network. Hepatology 49, 809–820 (2009).

    Article  Google Scholar 

  8. Colquitt, J. L., Picot, J., Loveman, E. & Clegg, A. J. Surgery for obesity. Cochrane Database Syst. Rev. 2, CD003641 (2009).

    Google Scholar 

  9. Adams, T. D. et al. Long-term mortality after gastric bypass surgery. N. Engl. J. Med. 357, 753–761 (2007).

    Article  CAS  Google Scholar 

  10. Sjostrom, L. et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N. Engl. J. Med. 357, 741–752 (2007).

    Article  Google Scholar 

Download references

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Correspondence to Helma P. Cotrim.

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The authors declare no competing financial interests.

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Cotrim, H., Daltro, C. Does bariatric surgery reduce the severity of NAFLD?. Nat Rev Gastroenterol Hepatol 7, 11–13 (2010). https://doi.org/10.1038/nrgastro.2009.215

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