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Conrad Hal Waddington: the last Renaissance biologist?

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Abstract

Conrad Hal Waddington was a leading embryologist and geneticist from the 1930s to the 1950s. He is remembered mainly for his concepts of the 'epigenetic landscape' and 'genetic assimilation'. This article reviews his life and work, and enquires to what extent his ideas are relevant tools for understanding the biological problems of today.

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Figure 1: Conrad Hal Waddington.
Figure 2: The existence of an organizer in higher vertebrates.
Figure 3: The epigenetic landscape.
Figure 4: The callosities on the ventral surface of the ostrich. The callosities are depicted by arrows.

References

  1. Robertson, A. Conrad Hal Waddington 8 November 1905–26 September 1975. Biogr. Mem. Fellows R. Soc. 23, 575–622 (1977).

    Article  CAS  Google Scholar 

  2. Waddington, C. H. in Towards a Theoretical Biology Vol. 2, 72–81 (Edinburgh Univ. Press, UK, 1969).

    Google Scholar 

  3. Spemann, H. & Mangold, H. Über Induktion von Embryonenanlagen durch Implantation artfremder Organisatoren. Arch. Microsk. Anat. EntwMech. 100, 599–638 (1924).

    Google Scholar 

  4. Waddington, C. H. Experiments on the development of chick and duck embryos cultivated in vitro. Phil. Trans. R. Soc. Lond. B Biol. Sci. 221, 179–230 (1932).

    Article  Google Scholar 

  5. Waddington, C. H. Experiments on determination in the rabbit embryo. Arch. Biol. 48, 273–290 (1937).

    Google Scholar 

  6. Bautzmann, H., Holtfreter, J., Spemann, H. & Mangold, O. Versuche zur Analyse der Induktionsmittel in der Embryonalentwicklung. Naturwissenschaften 20, 971–974 (1932).

    Article  Google Scholar 

  7. Witkowski, J. A. Optimistic analysis — chemical embryology in Cambridge 1920–42. Med. Hist. 31, 247–268 (1987).

    Article  CAS  Google Scholar 

  8. Dalcq, A. & Pasteels, J. Une conception nouvelle des bases physiologique de la morphogénèse. Arch. Biol. 48, 669–710 (1937).

    Google Scholar 

  9. Waddington, C. H., Needham, J. & Needham, D. M. Studies on the nature of the amphibian organisation centre. I. Chemical properties of the evocator. Proc. R. Soc. Lond. B Biol. Sci. 117, 289–310 (1935).

    Article  CAS  Google Scholar 

  10. Waddington, C. H., Needham, J. & Brachet, J. Studies on the nature of the amphibian organisation centre. III. The activation of the evocator. Proc. R. Soc. Lond. B Biol. Sci. 120, 173–198 (1936).

    Article  CAS  Google Scholar 

  11. Slack, J. M. W. Inducing factors in Xenopus early embryos. Curr. Biol. 4, 116–126 (1994).

    Article  CAS  Google Scholar 

  12. Waddington, C. H. Organisers and Genes (Cambridge Univ. Press, UK, 1940).

    Google Scholar 

  13. Waddington, C. H. The Strategy of the Genes (Geo Allen & Unwin, London, 1957).

    Google Scholar 

  14. Medvedev, R. The Rise and Fall of T. D. Lysenko (Columbia Univ. Press, New York, 1969).

    Google Scholar 

  15. Waddington, C. H. Canalization of development and the inheritance of acquired characters. Nature 150, 563–565 (1942).

    Article  Google Scholar 

  16. Waddington, C. H. Selection of the genetic basis for an acquired character. Nature 169, 278 (1952).

    Article  CAS  Google Scholar 

  17. Waddington, C. H. (ed.) Towards a Theoretical Biology Vols 1–4 (Edinburgh Univ. Press, UK, 1968–1972).

    Book  Google Scholar 

  18. Wolpert, L. Positional information and the spatial pattern of cellular differentiation. J. Theor. Biol. 25, 1–47 (1969).

    Article  CAS  Google Scholar 

  19. Thom, R. Structural Stability and Morphogenesis (Benjamin, Reading, Massachusetts, 1975).

    Google Scholar 

  20. Waddington, C. H. Principles of Embryology (Cambridge Univ. Press, UK, 1956).

    Google Scholar 

  21. Thomas, R. Boolean formalisation of genetic control circuits. J. Theor. Biol. 42, 563–585 (1973).

    Article  CAS  Google Scholar 

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Acknowledgements

I am grateful to A. McLaren, C. Stern and L. Wolpert for comments on the manuscript, but I know they do not necessarily agree with all my statements.

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Authors and Affiliations

  1. Department of Biology and Biochemistry, Developmental Biology Programme, University of Bath, Bath, BA2 7AY, UK

    Jonathan M. W. Slack

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Slack, J. Conrad Hal Waddington: the last Renaissance biologist?. Nat Rev Genet 3, 889–895 (2002). https://doi.org/10.1038/nrg933

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