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Using human genetics to make new medicines

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Abstract

Jeffrey Barrett, Ian Dunham and Ewan Birney discuss the initiatives of the newly founded Centre for Therapeutic Target Validation, including a range of approaches to use human genetics to inform drug discovery and make better medicines.

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Author information

Authors and Affiliations

  1. Centre for Therapeutic Target Validation,

    Jeffrey C. Barrett & Ian Dunham

  2. Wellcome Trust Sanger Institute,

    Jeffrey C. Barrett & Ian Dunham

  3. European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SD, UK

    Jeffrey C. Barrett, Ian Dunham & Ewan Birney

Authors
  1. Jeffrey C. Barrett
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  2. Ian Dunham
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  3. Ewan Birney
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Corresponding author

Correspondence to Jeffrey C. Barrett.

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Competing interests

E.B. is a paid consultant for Oxford Nanopore, a DNA sequencing company. J.C.B. and I.D. declare no competing interests.

Related links

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FURTHER INFORMATION

Accelerating Medicines Partnership

Centre for Therapeutic Target Validation

Genomics England

Precision Medicine Initiative

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Barrett, J., Dunham, I. & Birney, E. Using human genetics to make new medicines. Nat Rev Genet 16, 561–562 (2015). https://doi.org/10.1038/nrg3998

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  • DOI: https://doi.org/10.1038/nrg3998

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