High-resolution peripheral quantitative CT (HRpQCT) provides more detailed information than older methods. A new study shows that radial and tibial HRpQCT measurements are associated with incident fracture in postmenopausal women. However, it is unclear whether HRpQCT improves fracture risk prediction enough to justify its use in clinical practice.
This is a preview of subscription content, log in via an institution to check access.
References
Eastell, R. et al. Postmenopausal osteoporosis. Nat. Rev. Dis. Primers 2, 16069 (2016).
Khosla, S. et al. Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment. J. Bone Miner. Res. 21, 124–131 (2006).
Sornay-Rendu, E., Boutroy, S., Munoz, F. & Delmas, P. D. Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study. J. Bone Miner. Res. 22, 425–433 (2007).
Burt, L. A., Manske, S. L., Hanley, D. A. & Boyd, S. K. Lower bone density, impaired microarchitecture, and strength predict future fragility fracture in postmenopausal women: 5-year follow-up of the Calgary CaMos cohort. J. Bone Miner. Res. https://doi.org/10.1002/jbmr.3347 (2018).
Biver, E. et al. Evaluation of radius microstructure and areal bone mineral density improves fracture prediction in postmenopausal women. J. Bone Miner. Res. 33, 328–337 (2017).
Sornay-Rendu, E., Boutroy, S., Duboeuf, F. & Chapurlat, R. D. Bone microarchitecture assessed by HR-pQCT as predictor of fracture risk in postmenopausal women: the OFELY study. J. Bone Miner. Res. 32, 1243–1251 (2017).
Chapurlat, R. et al. The QUALYOR (QUalite Osseuse LYon Orleans) study: a new cohort for non invasive evaluation of bone quality in postmenopausal osteoporosis. Rationale and study design. Arch. Osteoporos. 13, 2 (2017).
Berger, C. et al. Association between change in BMD and fragility fracture in women and men. J. Bone Miner. Res. 24, 361–370 (2009).
Nguyen, T. V., Center, J. R. & Eisman, J. A. Femoral neck bone loss predicts fracture risk independent of baseline BMD. J. Bone Miner. Res. 20, 1195–1201 (2005).
Sornay-Rendu, E., Munoz, F., Duboeuf, F. & Delmas, P. D. Rate of forearm bone loss is associated with an increased risk of fracture independently of bone mass in postmenopausal women: the OFELY study. J. Bone Miner. Res. 20, 1929–1935 (2005).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
PowerPoint slides
Rights and permissions
About this article
Cite this article
Eastell, R., Walsh, J. Microarchitecture of bone predicts fractures in older women. Nat Rev Endocrinol 14, 255–256 (2018). https://doi.org/10.1038/nrendo.2018.27
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrendo.2018.27
- Springer Nature Limited