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Sweetener associated with increased adiposity in young adults

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Many students experience weight gain during their first year of college, which has been attributed to environmental changes, including eating habits and activity patterns. A new study implicates the endogenous metabolite and sugar substitute, erythritol, as a novel physiological marker predictive of vulnerability to increased adiposity.

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References

  1. Hootman, K. C. et al. Erythritol is a pentose-phosphate pathway metabolite and associated with adiposity gain in young adults. Proc. Natl Acad. Sci. USA 114, E4233–E4240 (2017).

    Article  CAS  Google Scholar 

  2. Sylvetsky, A. C. et al. Consumption of low-calorie sweeteners among children and adults in the United States. J. Acad. Nutr. Diet. 117, 441–448.e2 (2017).

    Article  Google Scholar 

  3. Bernt, W. O., Borzelleca, J. F., Flamm, G. & Munro, I. C. Erythritol: a review of biological and toxicological studies. Regul. Toxicol. Pharmacol. 24, S191–S197 (1996).

    Article  CAS  Google Scholar 

  4. Swithers, S. E. Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements. Trends Endocrinol. Metab. 24, 431–441 (2013).

    Article  CAS  Google Scholar 

  5. Shearer, J. & Swithers, S. E. Artificial sweeteners and metabolic dysregulation: lessons learned from agriculture and the laboratory. Rev. Endocr. Metab. Disord. 17, 179–186 (2016).

    Article  CAS  Google Scholar 

  6. Mitsutomi, K. et al. Effects of a nonnutritive sweetener on body adiposity and energy metabolism in mice with diet-induced obesity. Metabolism 63, 69–78 (2014).

    Article  CAS  Google Scholar 

  7. Hiele, M., Ghoos, Y., Rutgeerts, P. & Vantrappen, G. Metabolism of erythritol in humans: comparison with glucose and lactitol. Br. J. Nutr. 69, 169–176 (1993).

    Article  CAS  Google Scholar 

  8. Gupte, R. S. et al. Synergistic activation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase by Src kinase elevates superoxide in type 2 diabetic, Zucker fa/fa, rat liver. Free Radic. Biol. Med. 47, 219–228 (2009).

    Article  CAS  Google Scholar 

  9. Park, J. et al. Increase in glucose-6-phosphate dehydrogenase in adipocytes stimulates oxidative stress and inflammatory signals. Diabetes 55, 2939–2949 (2006).

    Article  CAS  Google Scholar 

  10. Szymanska, E. et al. Gender-dependent associations of metabolite profiles and body fat distribution in a healthy population with central obesity: towards metabolomics diagnostics. OMICS 16, 652–667 (2012).

    Article  CAS  Google Scholar 

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Acknowledgements

S.E.S. is funded by the National Heart, Lung and Blood Institute. J.S. is funded by the Natural Sciences and Engineering Research Council of Canada.

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Correspondence to Susan E. Swithers.

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Swithers, S., Shearer, J. Sweetener associated with increased adiposity in young adults. Nat Rev Endocrinol 13, 443–444 (2017). https://doi.org/10.1038/nrendo.2017.71

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