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Reproductive endocrinology

Iodine intake in pregnancy—even a little excess is too much

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Several studies have linked maternal iodine deficiency during pregnancy with adverse neurodevelopmental outcomes in offspring. A new study warns that excessive iodine exposure might also be detrimental to maternal thyroid health and recommends a lower limit for maternal iodine intake during pregnancy than that currently advised by the WHO.

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References

  1. Bath, S. C., Steer, C. D., Golding, J., Emmett, P. & Rayman, M. P. Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Lancet 382, 331–337 (2013).

    Article  CAS  Google Scholar 

  2. Shi, X. et al. Optimal and safe upper limits of iodine intake for early pregnancy in iodine-sufficient regions: a cross-sectional study of 7,190 pregnant women in China. J. Clin. Endocrinol. Metab. http://dx.doi.org/10.1210/jc.2014-3704.

  3. Leung, A. M. & Braverman, L. E. Consequences of excess iodine. Nat. Rev. Endocrinol. 10, 136–142 (2014).

    Article  CAS  Google Scholar 

  4. Ma, Z. F. & Skeaff, S. A. Thyroglobulin as a biomarker of iodine deficiency: a review. Thyroid 24, 1195–1209 (2014).

    Article  CAS  Google Scholar 

  5. König, F., Andersson, M., Hotz, K., Aeberli, I. & Zimmermann, M. B. Ten repeat collections for urinary iodine from spot samples or 24-hour samples are needed to reliably estimate individual iodine status in women. J. Nutr. 141, 2049–2054 (2011).

    Article  Google Scholar 

  6. Connelly, K. J. et al. Congenital hypothyroidism caused by excess prenatal maternal iodine ingestion. J. Pediatr. 161, 760–762 (2012).

    Article  Google Scholar 

  7. Morreale de Escobar, G., Obregón, M. J. & Escobar del Rey, F. Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? J. Clin. Endocrinol. Metab. 85, 3975–3987 (2000).

    CAS  PubMed  Google Scholar 

  8. WHO, UNICEF & ICCIDD. Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers World Health Organization [online], (2007).

  9. Institute of Medicine (US) Panel on Micronutrients. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. NCBI Bookself [online], (2001).

  10. Scientific Committee on Food & Scientific Panel on Dietetic Products, Nutrition and Allergies. Tolerable upper intake levels for vitamins and minerals. European Food Safety Authority [online], (2006).

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Acknowledgements

S.Y.L. would like to acknowledge the support of NIH grant T32DK007201-37.

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Authors and Affiliations

  1. Boston University School of Medicine, Section of Endocrinology, Diabetes, and Nutrition, 88 East Newton Street, H3600, Boston, 02118, MA, USA

    Sun Y. Lee & Elizabeth N. Pearce

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  1. Sun Y. Lee
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  2. Elizabeth N. Pearce
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Correspondence to Elizabeth N. Pearce.

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The authors declare no competing financial interests.

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Lee, S., Pearce, E. Iodine intake in pregnancy—even a little excess is too much. Nat Rev Endocrinol 11, 260–261 (2015). https://doi.org/10.1038/nrendo.2015.28

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