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Telomere length and the metabolic syndrome—a causal link?

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Shortening of leukocyte telomeres is considered a molecular marker for ageing and is suggested to be linked with increased risk of cardiovascular and metabolic disease. A large population-based study with 6 years of follow-up by Révész and colleagues reveals that short telomeres, at both baseline and during follow-up, are associated with an increased risk of metabolic abnormalities.

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References

  1. Tzanetakou, I. P., Nzietchueng, R., Perrea, D. N. & Benetos, A. Telomeres and their role in aging and longevity. Curr. Vasc. Pharmacol. 12, 726–734 (2014).

    Article  CAS  Google Scholar 

  2. Valdes, A. M. et al. Obesity, cigarette smoking, and telomere length in women. Lancet 366, 662–420 (2005).

    Article  CAS  Google Scholar 

  3. Fyhrquist, F., Saijonmaa, O. & Strandberg, T. The roles of senescence and telomere shortening in cardiovascular disease. Nat. Rev. Cardiol. 10, 274–283 (2013).

    Article  CAS  Google Scholar 

  4. Révész, D., Milaneschi, Y., Verhoeven, J. E. & Penninx, B. W. Telomere length as a marker of cellular ageing is associated with prevalence and progression of metabolic syndrome. J. Clin. Endocrinol. Metab. http://dx.doi.org/10.1210/jc.2014-1851.

  5. Haycock, P. C et al. Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis. BMJ 349, g4227 (2014).

    Article  Google Scholar 

  6. Codd, V. et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat. Genet. 45, 422–427 (2013).

    Article  CAS  Google Scholar 

  7. Vasan, R. S. et al. Association of leukocyte telomere length with echocardiographic left ventricular mass: the Framingham heart study. Circulation 120, 1195–1202 (2009).

    Article  Google Scholar 

  8. Kuznetsova, T. et al. Association between left ventricular mass and telomere length in a population study. Am. J. Epidemiol. 172, 440–450 (2010).

    Article  Google Scholar 

  9. Nilsson, P. M., Tufvesson, H., Leosdottir, M. & Melander, O. Telomeres and cardiovascular disease risk: an update. Transl. Res. 162, 371–380 (2013).

    Article  CAS  Google Scholar 

  10. Ornish, D. et al. Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet Oncol. 14, 1112–1120 (2013).

    Article  CAS  Google Scholar 

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Acknowledgements

P.M.N. has received grant support the Swedish Research Council for a project on early vascular ageing.

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  1. Department of Clinical Sciences, Lund University, Skåne University Hospital, IM Nilssons gata 32, 2nd floor, Malmö, S-205 02, Sweden

    Peter M. Nilsson

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  1. Peter M. Nilsson
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Correspondence to Peter M. Nilsson.

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Nilsson, P. Telomere length and the metabolic syndrome—a causal link?. Nat Rev Endocrinol 10, 706–707 (2014). https://doi.org/10.1038/nrendo.2014.182

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