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Reproductive endocrinology

Revisiting ovulation induction in PCOS

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Polycystic ovary syndrome (PCOS) is associated with anovulatory infertility. Many clinicians focus on the use of assisted reproductive technologies other than medical induction of ovulation. A new study demonstrating that the aromatase inhibitor letrozole is superior to clomiphene citrate (the current first-line therapy) for ovulation induction in women with PCOS returns attention to this area.

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Authors and Affiliations

  1. Department of Reproductive Medicine & Gynecology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, 3584 CX, Netherlands

    Bart C. J. M. Fauser

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  1. Bart C. J. M. Fauser
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Correspondence to Bart C. J. M. Fauser.

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Competing interests

B.C.J.M.F. has received consultancy fees and grant support from the following companies: Andromed, Ardana, COGI, Euroscreen, Ferring, Gedeon-Richter, Genovum, Merck Serono, MSD, Organon, Ova-Science, Pantharei Bioscience, PregLem, Roche, Schering, Schering Plough, Serono, Uteron, Watson Laboratories and Wyeth.

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Fauser, B. Revisiting ovulation induction in PCOS. Nat Rev Endocrinol 10, 704–705 (2014). https://doi.org/10.1038/nrendo.2014.156

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