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Increased fracture risk with HIV infection—a growing concern

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HIV infection and antiretroviral therapy have long been associated with an increased risk of osteopenia and osteoporosis. This predisposition has now been shown to result in a significantly increased risk of osteoporotic fractures in the HIV-infected population even after controlling for known risk factors.

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Figure 1: Determinants of increased fracture risk in patients with HIV infection.

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Acknowledgements

R. Bedimo is supported by VA MERIT grant I01 CX000418-01A1. P. Tebas is supported by grant AI045008.

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Correspondence to Pablo Tebas.

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Bedimo, R., Tebas, P. Increased fracture risk with HIV infection—a growing concern. Nat Rev Endocrinol 9, 260–261 (2013). https://doi.org/10.1038/nrendo.2013.62

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