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Adrenal cancer in 2013

Time to individualize treatment for adrenocortical cancer?

  • Year in Review
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2013 was a good year for adrenocortical cancer, as the new knowledge gained holds great promise for patients. Advances were made in genetics, epigenetics, the advent of related technological and bioinformatic tools, and the feasibility of massive screening of people and samples.

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Figure 1: Hyperplasia–adenoma–carcinoma sequence and molecular heterogeneity in adrenocortical cancer.

References

  1. Ribeiro, R. C. et al. An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma. Proc. Natl Acad. Sci. USA 98, 9330–9335 (2001).

    Article  CAS  Google Scholar 

  2. Fassnacht, M. et al. Combination chemotherapy in advanced adrenocortical carcinoma. N. Engl. J. Med. 366, 2189–2197 (2012).

    Article  CAS  Google Scholar 

  3. Kandoth, C. et al. Mutational landscape and significance across 12 major cancer types. Nature 502, 333–339 (2013).

    Article  CAS  Google Scholar 

  4. Stratakis, C. A. Genetics of adrenocortical tumors: gatekeepers, landscapers and conductors in symphony. Trends Endocrinol. Metab. 14, 404–410 (2003).

    Article  CAS  Google Scholar 

  5. Marjanovic, N. D., Weinberg, R. A. & Chaffer, C. L. Cell plasticity and heterogeneity in cancer. Clin. Chem. 59, 168–179 (2013).

    Article  CAS  Google Scholar 

  6. Drelon, C., Berthon, A. & Val, P. Adrenocortical cancer and IGF2: is the game over or our experimental models limited? J. Clin. Endocrinol. Metab. 98, 505–507 (2013).

    Article  CAS  Google Scholar 

  7. Custódio, G. et al. Impact of neonatal screening and surveillance for the TP53 R337H mutation on early detection of childhood adrenocortical tumors. J. Clin. Oncol. 31, 2619–2626 (2013).

    Article  Google Scholar 

  8. Ronchi, C. L. et al. Single nucleotide polymorphism array profiling of adrenocortical tumors - evidence for an adenoma carcinoma sequence? PLoS ONE 8, e73959 (2013).

    Article  CAS  Google Scholar 

  9. Gaujoux, S. et al. Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R. PLoS ONE 8, e55743 (2013).

    Article  CAS  Google Scholar 

  10. De Martino, M. C. et al. Molecular screening for a personalized treatment approach in advanced adrenocortical cancer. J. Clin. Endocrinol. Metab. 98, 4080–4088 (2013).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The author's work was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD).

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  1. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), CRC Room 1-3330, East Laboratories, Building 10-CRC, 10 Center Drive, SEGEN/PDEGEN, NICHD, NIH, Bethesda, 20892, MD, USA

    Constantine A. Stratakis

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Correspondence to Constantine A. Stratakis.

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Stratakis, C. Time to individualize treatment for adrenocortical cancer?. Nat Rev Endocrinol 10, 76–78 (2014). https://doi.org/10.1038/nrendo.2013.263

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