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Autoimmunity

Does celiac disease trigger autoimmune thyroiditis?

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Autoimmune thyroiditis has increased prevalence in patients with celiac disease and vice versa. New research suggests that serum transglutaminase 2 autoantibodies, which are present in patients with celiac disease, might have a role in the development of thyroid dysfunction.

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Figure 1: IgA autoantibodies against transglutaminase 2 present in the sera of patients with active celiac disease bind to this enzyme in thyroid tissue.

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Acknowledgements

I would like to thank Ms Maria Panoutsopoulou for her valuable assistance in the preparation of this manuscript.

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  1. Endocrine Unit, Evgenidion Hospital, University of Athens Medical School, 20 Papadiamantopoulou Street, 115 28 Athens, Greece ledunt@otenet.gr

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  1. Endocrine Unit, Evgenidion Hospital, University of Athens Medical School, Athens, Greece

    Leonidas H. Duntas

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  1. Leonidas H. Duntas
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Duntas, L. Does celiac disease trigger autoimmune thyroiditis?. Nat Rev Endocrinol 5, 190–191 (2009). https://doi.org/10.1038/nrendo.2009.46

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