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Towards host-directed therapies for tuberculosis

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Abstract

The treatment of tuberculosis is based on combinations of drugs that directly target Mycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.

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Change history

  • 04 August 2015

    The spelling of Voahangy Rasolofo's name has been corrected.

References

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Author information

Authors and Affiliations

  1. Division of Infection and Immunity at the University College London (UCL), London, UK

    Alimuddin Zumla, Mahdad Noursadeghi & Timothy D. McHugh

  2. National Institute of Health Research's Biomedical Research Centre UCL Hospitals National Health Service Foundation Trust, Royal Free Campus, 2nd Floor, Rowland Hill Street, London, NW3 2PF, UK

    Alimuddin Zumla, Mahdad Noursadeghi & Timothy D. McHugh

  3. Department of Laboratory Medicine, Therapeutic Immunology, Karolinska Institutet and Center for Allogeneic Stem Cell Transplantation, Karolinska Hospital, Hälsovägen, Stockholm, SE-14186, Sweden

    Shreemanta Parida, Martin Rao & Markus Maeurer

  4. Kenya Medical Research Institute, Nairobi, Kenya

    Jeremiah Chakaya

  5. Division of Infectious Diseases and Tropical Medicine, Medical Centre of the University of Munich (LMU), and DZIF German Centre for Infection Research, Munich, Germany

    Michael Hoelscher

  6. Fondation Congolaise pour la Recherche Médicale, Brazzaville, Republic of Congo

    Francine Ntoumi

  7. Institute for Tropical Medicine, University of Tübingen, Germany

    Francine Ntoumi

  8. Medical Research Council, Cape Town, South Africa

    Roxana Rustomjee

  9. Unitat de Tuberculosi Experimental Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i PujolEdifici Laboratoris de Recerca Can Ruti Campus, Barcelona, Spain

    Cristina Vilaplana & Pere-Joan Cardona

  10. Bacteriology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana

    Dorothy Yeboah-Manu

  11. Mycobacteria Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar

    Voahangy Rasolofo & Niaina Rakotosamimanana

  12. Medical Research Council/Uganda Virus Research Institute, Research Unit on AIDS, Entebbe, Uganda

    Paula Munderi

  13. Inkosi Albert Luthuli Central Hospital and King DinuZulu Hospital, Durban, South Africa

    Nalini Singh

  14. Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden

    Eleni Aklillu

  15. Centre for AIDS Prevention Research in South Africa (CAPRISA), SAMRC CAPRISA HIV -TB pathogenesis and treatment research unit, Durban, South Africa

    Nesri Padayatchi

  16. Centro de Investigação em Saude de Manhiça, Maputo, Mozambique

    Eusebio Macete & Alberto Garcia-Basteiro

  17. UNZA-UCLMS Research and Training Project, University Teaching Hospital, Lusaka, Zambia

    Nathan Kapata, Matthew Bates & Peter Mwaba

  18. Tropical Diseases Research Centre, Ndola, Zambia

    Modest Mulenga

  19. Kilimanjaro Clinical Research Institute (KCRI), Kilimanjaro, Tanzania

    Gibson Kibiki

  20. Muhimbili Medical Research Centre National Institute for Medical Research (NIMR), Dar es Salaam, Tanzania

    Sayoki Mfinanga

  21. European Developing Countries Clinical Trials Partnership (EDCTP), Cape Town, South Africa; not officially a partner of this consortium but participated in the HDT-NET Cape Town launch.,

    Thomas Nyirenda

  22. not officially a partner of this consortium but participated in the HDT-NET Cape Town launch.,

    Thomas Nyirenda

  23. Mbeya Medical Research Centre, Mbeya, Tanzania

    Leonard Maboko

  24. Swiss Tropical and Public Health Institute, Basel, Switzerland

    Klaus Reither & Sebastien Gagneux

  25. Ethics and Governance, NIHR BRC at University College London Hospitals NHS Trust, London, United Kingdom

    Sarah Edwards

  26. Ifakara Health Institute, Bagamoyo, Tanzania

    Elirehema Mfinanga

  27. Ifakara Health Institute, Dar-es-Salaam, Tanzania

    Salim Abdulla

  28. Department of Internal Medicine, Connaught Hospital, College of Medicine and Allied Health Sciences, University of Sierra Leone, Sierra Leone

    James B.W. Russell

  29. Department of Microbiology, University College London Hospitals NHS Foundation Trust, London, UK

    Alimuddin Zumla, Vanya Gant & Mahdad Noursadeghi

  30. Respiratory Medicine department, Southampton University, Southampton, UK

    Paul Elkington

  31. Epicentre, IRD, Paris, France

    Maryline Bonnet

  32. ISGlobal, Barcelona Institute for Global health, Barcelona, Spain. Immunology Unit-Laboratoire Bactériologie Virologie, Le Dantec,

    Clara Menendez

  33. Hospital, Laboratories of the National Blood Transfusion Center, Senegal

    Tandakha N. Dieye

  34. SEREFO (HIV/TB Research and Training CenteHIV/TB Research and Training Center, FMOS, University of STT, Bamako, Mali

    Bassirou Diarra & Almoustapha Maiga

  35. Armaeur Hansen Resrach Institute (AHRI), Addis Ababa, Ethiopia

    Abraham Aseffa

  36. Department of Infectious Diseases, Aarhus University, Aarhus, Denmark

    Christian Wejse & Eskild Petersen

  37. Medical Research Council/Uganda Virus Research Institute, Research Unit on AIDS, Entebbe, Uganda

    Pontiano Kaleebu

  38. Results UK, London, United Kingdom

    Matt Oliver

  39. School of Health Sciences, City University London, City University, London, UK

    Gill Craig

  40. Department of Infectious and Tropical Diseases, Northwick Park Hospital, London, UK

    Tumena Corrah

  41. Medical Research Council, Banjul, Gambia

    Leopold Tientcheu & Martin Antonio

  42. Centre of Medical Informatics, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, UK

    Aziz Sheikh

  43. National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy

    Giuseppe Ippolito

  44. HIV prevention Research Unit, MRC, Durban, South Africa

    Gita Ramjee

  45. Max Planck Institute, Berlin, Germany

    Stefan H. E. Kaufmann

  46. Aurum Institute, Johannesburg, South Africa

    Gavin Churchyard & Robert S. Wallis

  47. KwaZulu-Natal Research Institute for Tuberculosis & HIV, Nelson R. Mandela School of Medicine, K-RITH Tower Building, Durban, South Africa

    Andrie Steyn

  48. Department of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, University of Amsterdam, Amsterdam, The Netherlands

    Martin Grobusch

  49. Right to care, University of Witwatersrand, Johannesburg, South Africa

    Ian Sanne

  50. Public Health research Unit, Soweto, South Africa

    Neil Martinson

  51. Department of Cardiothoracic Surgery, University of KwaZulu Natal, Inkosi Albert Luthuli Central Hospital and King DinuZulu Hospital, Durban, South Africa

    Rajhmun Madansein

  52. Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa and Francis Crick Institute Mill Hill Laboratory, London, UK

    Robert J. Wilkinson

  53. Department of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South Africa

    Bongani Mayosi

  54. Critical Path to TB Drug Regimens, Critical Path Institute, Tucson, Arizona, USA

    Marco Schito

Authors
  1. Alimuddin Zumla
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  2. Jeremiah Chakaya
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  3. Michael Hoelscher
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  4. Francine Ntoumi
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  5. Roxana Rustomjee
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  6. Cristina Vilaplana
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  7. Dorothy Yeboah-Manu
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  8. Voahangy Rasolofo
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  9. Paula Munderi
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  10. Nalini Singh
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  11. Eleni Aklillu
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  12. Nesri Padayatchi
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  13. Eusebio Macete
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  14. Nathan Kapata
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  15. Modest Mulenga
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  16. Gibson Kibiki
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  17. Sayoki Mfinanga
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  18. Thomas Nyirenda
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  19. Leonard Maboko
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  20. Alberto Garcia-Basteiro
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  21. Niaina Rakotosamimanana
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  22. Matthew Bates
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  23. Peter Mwaba
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  24. Klaus Reither
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  25. Sebastien Gagneux
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  26. Sarah Edwards
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  27. Elirehema Mfinanga
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  28. Salim Abdulla
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  29. Pere-Joan Cardona
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  30. James B.W. Russell
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  31. Vanya Gant
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  32. Mahdad Noursadeghi
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  33. Paul Elkington
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  34. Maryline Bonnet
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  35. Clara Menendez
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  36. Tandakha N. Dieye
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  37. Bassirou Diarra
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  38. Almoustapha Maiga
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  39. Abraham Aseffa
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  40. Shreemanta Parida
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  41. Christian Wejse
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  42. Eskild Petersen
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  43. Pontiano Kaleebu
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  44. Matt Oliver
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  45. Gill Craig
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  46. Tumena Corrah
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  47. Leopold Tientcheu
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  48. Martin Antonio
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  49. Martin Rao
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  50. Timothy D. McHugh
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  51. Aziz Sheikh
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  52. Giuseppe Ippolito
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  53. Gita Ramjee
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  54. Stefan H. E. Kaufmann
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  55. Gavin Churchyard
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  56. Andrie Steyn
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  57. Martin Grobusch
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  58. Ian Sanne
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  59. Neil Martinson
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  60. Rajhmun Madansein
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  61. Robert J. Wilkinson
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  62. Bongani Mayosi
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  63. Marco Schito
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  64. Robert S. Wallis
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  65. Markus Maeurer
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Corresponding authors

Correspondence to Alimuddin Zumla or Markus Maeurer.

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Competing interests

The authors declare no competing financial interests.

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Supplementary information

Supplementary information S1 (table)

Interventions under investigation as host-directed therapies for tuberculosis (PDF 282 kb)

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Zumla, A., Chakaya, J., Hoelscher, M. et al. Towards host-directed therapies for tuberculosis. Nat Rev Drug Discov 14, 511–512 (2015). https://doi.org/10.1038/nrd4696

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