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Preclinical target validation using patient-derived cells

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Abstract

The Structural Genomics Consortium (SGC) and its clinical, industry and disease-foundation partners are launching open-source preclinical translational medicine studies.

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Author information

Authors and Affiliations

  1. Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, M5G 1L7, Ontario, Canada

    Aled M. Edwards, Cheryl H. Arrowsmith, Panagiotis Prinos, Dalia Barsyte & Evelyne Lima-Fernandes

  2. Nuffield Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7LD, UK

    Chas Bountra, Opher Gileadi, Stefan Knapp, Wen Hwa Lee & Katlin B. Massirer

  3. Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Cambridge, 02139, Massachusetts, USA

    Mark E. Bunnage

  4. Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7FY, UK

    Marc Feldmann & Jagdeep Nanchahal

  5. Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK

    Julian C. Knight

  6. Novartis Institutes for BioMedical Research, Basel, CH-4002, Switzerland

    Dhavalkumar D. Patel, Nils Ostermann & Hans Widmer

  7. Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Ontario, Canada

    Michael D. Taylor & Peter Dirks

  8. Department of Medicine, Structural Genomics Consortium, Karolinska University Hospital and Karolinska Institutet, Stockholm, 171 76, Sweden

    Michael Sundström

  9. Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, H3A 2B4, Quebec, Canada

    Phil Barker & Edward A. Fon

  10. Department of Biochemistry and Tissue Biology, Institute of Biology, State University of Campinas (UNICAMP), Avenue Monteiro Lobato 255, Campinas, 13083-970, So Paulo, Brazil

    Mario H. Bengtson

  11. 150, rue Metcalfe Street, Suite 2100, Ottawa, K2P 1P1, Ontario, Canada

    Cindy Bell

  12. Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Science, Oxford, OX3 7LD, UK

    Paul Bowness

  13. Childrens Hospital of Eastern Research Institute, 401 Smyth Rd Ottawa, K1H 8L1, Ontario, Canada

    Kym M. Boycott & Alex E. MacKenzie

  14. Oncology Research & Development, GlaxoSmithKline, Collegeville, 19426, Pennsylvania, USA

    Carolyn Buser-Doepner & Christopher L. Carpenter

  15. NIHR Oxford Biomedical Research Unit, Botnar Research Centre, University of Oxford, Windmill Road, Oxford, OX3 7LD, UK

    Andrew J. Carr

  16. Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA

    Kirk Clark

  17. Janssen R&D, Immunology, 1400 McKean Road, Spring House, 19477, Pennsylvania, USA

    Anuk M. Das

  18. Discovery Sciences, Janssen Pharmaceuticals, 1400 McKean Road, Spring House, 19477, Pennsylvania, USA

    Dashyant Dhanak, Christopher Flores & Trevor Howe

  19. Program in Developmental and Stem Cell Biology, Hospital for Sick Children, 686 Bay Street, Toronto, Ontario M5G 1A4, Canada.,

    James Ellis

  20. Oncology Research Unit, Pfizer Worldwide Research & Development, 10724 Science Center Dr, San Diego, 92121, California, USA

    Valeria R. Fantin & Dominique Verhelle

  21. Allergan Research and Development, 2525 Dupont Avenue, Irvine, California 92612, USA.,

    Donald E. Frail

  22. Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, 02115, Massachusetts, USA

    Ronan C. O'Hagan

  23. Wellcome Trust, Gibbs Building, 215 Euston Road, London, NW1 2BE, UK

    John T. R. Isaac

  24. Montreal Childrens Hospital Research Institute, McGill University Health Center, St Catherine West, Suite 239, Montreal, 4060, H3Z 2Z3, Quebec, Canada

    Nada Jabado

  25. Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden

    Per-Johan Jakobsson, Lars Klareskog & Ingrid E. Lundberg

  26. Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, M5B 1W8, Ontario, Canada

    John Marshall

  27. Pharmaceutical Research Division, Takeda Pharmaceutical Co., Ltd, 2-26-1 Muraoka Higashi, Fujisawa, 251-8555, Japan

    Tetsuyuki Maruyama

  28. Bayer Pharma AG, Global Drug Discovery, Berlin, 13353, Germany

    Anke Mueller-Fahrnow

  29. Princess Margaret Cancer Centre, University Health Network, 101 College Street, Toronto, M5G 1L7, Ontario, Canada

    Cheryl H. Arrowsmith, Senthil Muthuswamy & Catherine O'Brien

  30. Botnar Research Centre, University of Oxford, Oxford, OX3 7DQ, UK

    Udo Oppermann

  31. Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University, Montreal, H3A 2B4, Quebec, Canada

    Kevin Petrecca, Viviane Poupon & Guy Rouleau

  32. Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON M5S 2S1, Canada

    Bruce G. Pollock

  33. Epinova Epigenetics DPU, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, Hertfordshire, UK

    Rab K. Prinjha

  34. AbbVie, 1 North Waukegan Road, North Chicago, 60064-6098, Illinois, USA

    Saul H. Rosenberg

  35. R&D Worldwide Business Development, GSK, Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK

    Malcolm Skingle

  36. St. Michael's Hospital & University of Toronto, 30 Bond Street, Toronto, M5B 1W8, Ontario, Canada

    Arthur S. Slutsky

  37. Ontario Brain Institute, 438 University Ave, Suite 1618, Toronto, M5G 2K8, Ontario, Canada

    Garth A. M. Smith

  38. University of Toronto, 1 Kings College Circle, Toronto, M5S 1A8, Ontario, Canada

    L. Trevor Young

Authors
  1. Aled M. Edwards
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  2. Cheryl H. Arrowsmith
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  3. Chas Bountra
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  4. Mark E. Bunnage
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  5. Marc Feldmann
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  6. Julian C. Knight
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  7. Dhavalkumar D. Patel
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  8. Panagiotis Prinos
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  9. Michael D. Taylor
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  10. Michael Sundström
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  11. Phil Barker
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  12. Dalia Barsyte
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  13. Mario H. Bengtson
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  14. Cindy Bell
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  15. Paul Bowness
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  16. Kym M. Boycott
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  17. Carolyn Buser-Doepner
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  18. Christopher L. Carpenter
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  19. Andrew J. Carr
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  20. Kirk Clark
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  21. Anuk M. Das
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  22. Dashyant Dhanak
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  23. Peter Dirks
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  24. James Ellis
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  25. Valeria R. Fantin
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  26. Christopher Flores
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  27. Edward A. Fon
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  28. Donald E. Frail
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  29. Opher Gileadi
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  30. Ronan C. O'Hagan
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  31. Trevor Howe
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  32. John T. R. Isaac
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  33. Nada Jabado
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  34. Per-Johan Jakobsson
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  35. Lars Klareskog
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  36. Stefan Knapp
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  37. Wen Hwa Lee
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  38. Evelyne Lima-Fernandes
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  39. Ingrid E. Lundberg
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  40. John Marshall
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  41. Katlin B. Massirer
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  42. Alex E. MacKenzie
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  43. Tetsuyuki Maruyama
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  44. Anke Mueller-Fahrnow
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  45. Senthil Muthuswamy
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  46. Jagdeep Nanchahal
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  47. Catherine O'Brien
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  48. Udo Oppermann
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  49. Nils Ostermann
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  50. Kevin Petrecca
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  51. Bruce G. Pollock
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  52. Viviane Poupon
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  53. Rab K. Prinjha
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  54. Saul H. Rosenberg
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  55. Guy Rouleau
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  56. Malcolm Skingle
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  57. Arthur S. Slutsky
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  58. Garth A. M. Smith
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  59. Dominique Verhelle
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  60. Hans Widmer
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  61. L. Trevor Young
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Corresponding author

Correspondence to Michael Sundström.

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The authors declare no competing financial interests.

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Edwards, A., Arrowsmith, C., Bountra, C. et al. Preclinical target validation using patient-derived cells. Nat Rev Drug Discov 14, 149–150 (2015). https://doi.org/10.1038/nrd4565

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