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Harnessing the informatics revolution for neuroscience drug R&D

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An Erratum to this article was published on 01 September 2014

This article has been updated

Several changes to scientific culture and policy are needed to aid the identification of new drug targets and therapies for central nervous system disorders from the rapidly growing volume of 'big' data in neuroscience.

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Change history

  • 01 September 2014

    The middle initial of the second author was incorrect; it should be Thomas R. Insel, as above. The online versions have been corrected accordingly.

References

  1. Shen, L., et al. Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers. Brain Imaging Behav. 8, 183–207 (2014).

    Article  CAS  Google Scholar 

  2. Chiang, M. C. et al. Gene network effects on brain microstructure and intellectual performance identified in 472 twins. J. Neurosci. 32, 8732–8745 (2012).

    Article  CAS  Google Scholar 

  3. Denny, J. C. et al. Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nature Biotech. 31, 1102–1110 (2013).

    Article  CAS  Google Scholar 

  4. Samtani, M. N. et al. An improved model for disease progression in patients from the Alzheimer's disease neuroimaging initiative. J. Clin. Pharmacol. 52, 629–644 (2012).

    Article  Google Scholar 

  5. Yuan, L. et al. Multi-source feature learning for joint analysis of incomplete multiple heterogeneous neuroimaging data. Neuroimage 61, 622–632 (2012).

    Article  Google Scholar 

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Correspondence to Husseini K. Manji.

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The authors declare no competing financial interests.

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Further information

Accelerating Medicines Partnership

Alzheimer's Disease Neuroimaging Initiative

Allen Brain Initiative

Blue Brain Project

Brain Research through Advancing Innovative Neurotechnologies

Human Brain Project

Human Connectome Project

National Database for Autism Research

Psychiatric Genomics Consortium

The Biomarkers Consortium

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Manji, H., Insel, T. & Narayan, V. Harnessing the informatics revolution for neuroscience drug R&D. Nat Rev Drug Discov 13, 561–562 (2014). https://doi.org/10.1038/nrd4395

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