Author information
Authors and Affiliations
Supplementary information
Supplementary information S1 (box)
Methodology to estimate the internal rate of return on R&D investments (PDF 296 kb)
Rights and permissions
About this article
Cite this article
David, E., Tramontin, T. & Zemmel, R. Pharmaceutical R&D: the road to positive returns. Nat Rev Drug Discov 8, 609–610 (2009). https://doi.org/10.1038/nrd2948
Issue Date:
DOI: https://doi.org/10.1038/nrd2948
- Springer Nature Limited
This article is cited by
-
SRChing for the substrates of Src
Oncogene (2014)
-
The discovery of first-in-class drugs: origins and evolution
Nature Reviews Drug Discovery (2014)
-
The Paradox of Scientific Excellence and the Search for Productivity in Pharmaceutical Research and Development
Clinical Pharmacology & Therapeutics (2014)