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Multiple myeloma therapies

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Figure 1: Prevalence of multiple myeloma and impact of new therapies.
Figure 2: Market for multiple myeloma therapies.

References

  1. Richardson, P. New treatments for myeloma. Oncology 14, 1781–1992 (2005).

    Google Scholar 

  2. Richardson, P. G. et al. Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N. Engl. J. Med. 352, 2487–2498 (2005).

    Article  CAS  Google Scholar 

  3. Mateos, M. V. et al. Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study. Blood 108, 2165–2172 (2006).

    Article  CAS  Google Scholar 

  4. Rajkumar, S. V. et al. Phase III clinical trial of thalidomide plus dexamethasone compared with dexamethasone alone in newly diagnosed multiple myeloma: a clinical trial coordinated by the Eastern Cooperative Oncology Group. J. Clin. Oncol. 24, 431–436 (2006).

    Article  CAS  Google Scholar 

  5. Facon, T. et al. Superiority of melphalan–prednisone (MP) + thalidomide (THAL) over MP and autologous stem cell transplantation in the treatment of newly diagnosed elderly patients with multiple myeloma. J. Clin. Oncol. 24 (Suppl. 18), Abstract 1 (2006).

  6. Weber, D. et al. Lenalidomide plus high-dose dexamethasone provides improved overall survival compared to high-dose dexamethasone alone for relapsed or refractory multiple myeloma (MM): results of 2 Phase III studies (MM-009, MM-010) and subgroup analysis of patients with impaired renal function. Blood 108 (ASH Annual Meeting Abstracts), Abstract 3547 (2006).

  7. Palumbo, A. et al. Oral revlimid plus melphalan and prednisone (R-MP) for newly diagnosed multiple myeloma: results of a multicenter Phase I/II study. Blood 108 (ASH Annual Meeting Abstracts), Abstract 800 (2006).

  8. Mitsiades, C. S. et al. Antimyeloma activity of heat shock protein-90 inhibition. Blood 107,1092–1100 (2006).

    Article  CAS  Google Scholar 

  9. Schey, S. A. et al. Phase I study of an immunomodulatory thalidomide analog, CC-4047, in relapsed or refractory multiple myeloma. J. Clin. Oncol. 22, 3269–3276 (2004).

    Article  CAS  Google Scholar 

  10. Hideshima, T. et al. Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood 107, 4053–4062 (2006).

    Article  CAS  Google Scholar 

  11. Silvestris, F. Myeloma bone disease: pathogenetic mechanisms and clinical assessment. Leuk. Res. 30, 1016–1020 (2006).

    Google Scholar 

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Authors and Affiliations

  1. Matthew Strobeck is at Westfield Capital Management, One Financial Center, 24th Floor, Boston, 02111-262, Massachusetts, USA

    Matthew Strobeck

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  1. Matthew Strobeck
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Competing interests

Both the author and his employer have or have had beneficial interests in shares of companies mentioned in the article.

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FURTHER INFORMATION

Multiple Myeloma Research Foundation

The International Myeloma Foundation

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Strobeck, M. Multiple myeloma therapies. Nat Rev Drug Discov 6, 181–182 (2007). https://doi.org/10.1038/nrd2269

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