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Cetuximab

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Abstract

Cetuximab (Erbitux; ImClone Systems/Bristol-Myers Squibb) is a monoclonal antibody that binds to the epidermal growth factor receptor, which is important in the growth of many cancers. In February 2004, it was granted accelerated approval by the FDA for the treatment of metastatic colorectal cancer on the basis of tumour response rates in Phase II trials.

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Figure 1: EGFR and the mode of action of cetuximab.
Figure 2: Market for drugs to treat colorectal cancer in US $ million.

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Authors and Affiliations

  1. Nature Reviews Drug Discovery,

    Peter Kirkpatrick

  2. Decision Resources International, 50–51 Russell Square, London, WC1B 4HQ, UK

    Joanne Graham & Mohamed Muhsin

Authors
  1. Peter Kirkpatrick
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  2. Joanne Graham
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  3. Mohamed Muhsin
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Corresponding author

Correspondence to Joanne Graham.

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Kirkpatrick, P., Graham, J. & Muhsin, M. Cetuximab. Nat Rev Drug Discov 3, 549–550 (2004). https://doi.org/10.1038/nrd1445

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