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Eplerenone

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Abstract

In September 2002, eplerenone (Inspra; Pharmacia), the first selective aldosterone receptor antagonist, was approved by the FDA for the treatment of hypertension. Will it become as successful as established blockbuster drugs that also target the renin–angiotensin–aldosterone system?

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Figure 1: Aldosterone antagonism.
Figure 2: Number of cases of hypertension.
Figure 3: Sales for antihypertensive drugs in US $ billion.

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Authors and Affiliations

  1. Decision Resources Intl, 50–51 Russell Square, London, WC1B 4HQ, UK

    Ruth Brown, Jeremy Quirk & Peter Kirkpatrick

Authors
  1. Ruth Brown
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  2. Jeremy Quirk
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  3. Peter Kirkpatrick
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Correspondence to Ruth Brown.

Additional information

Peter Kirkpatrick is Senior Editor of Nature Reviews Drug Discovery. Ruth Brown and Jeremy Quirk are Analysts

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Brown, R., Quirk, J. & Kirkpatrick, P. Eplerenone. Nat Rev Drug Discov 2, 177–178 (2003). https://doi.org/10.1038/nrd1039

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