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Prostate cancer

Clinical hallmarks in whole cancer genomes

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From Nature Reviews Clinical Oncology

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Fraser and colleagues describe the whole-genome sequencing (WGS) profiles of over 200 localized intermediate-risk prostate cancers. WGS has been widely used in research but not, thus far, in clinical settings. Herein, we consider the possible use of WGS in the field of precision oncology.

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Figure 1: Illustration of three complex somatic mutational phenomena frequently seen in the whole genomes of both prostate cancers and those of other tumour types.

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Acknowledgements

The authors would like to thank Dmitry Gordenin PhD of the National Institute of Environmental Health Sciences for his helpful comments and suggestions.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Marcin Imielinski is at The Englander Institute for Precision Medicine, The Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College–New York Presbyterian Hospital, 413 East 69th Street, 14th floor, New York, New York 10021, USA,

    Marcin Imielinski

  2. at New York Genome Center, 101 Avenue of the Americas, New York, New York, 10013, USA.,

    Marcin Imielinski

  3. Department of Pathology and Laboratory Medicine, Mark A. Rubin is at The Englander Institute for Precision Medicine, The Sandra and Edward Meyer Cancer Center, Weill Cornell Medical College–New York Presbyterian Hospital, 413 East 69th Street, 14th floor, New York, New York 10021, USA.,

    Mark A. Rubin

Authors
  1. Marcin Imielinski
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  2. Mark A. Rubin
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Correspondence to Marcin Imielinski or Mark A. Rubin.

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The authors declare no competing financial interests.

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Imielinski, M., Rubin, M. Clinical hallmarks in whole cancer genomes. Nat Rev Clin Oncol 14, 265–266 (2017). https://doi.org/10.1038/nrclinonc.2017.45

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