The rise of targeted therapy for solid tumours over the past decade has yielded a cornucopia of novel agents across an array of cancers. Amidst multiple acclaimed successes, targeted therapies are associated with considerable toxicity, and durable responses are often thwarted by genomic chaos driving the evolution of resistant clones; key examples of successes in solid tumours are highlighted herein.
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J.W.N. has received grants for research support from, ArQule, Boehringer-Ingelheim, Merck, and Roche/Genentech. G.W.S. has received grants for research support from Roche/Genentech and honouraria for speaking from Genentech, is a consultant for Symphogen, and is a member of the Board of Directors for Syndax Pharmaceuticals.
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Supplementary Table 1
FDA-approved targeted therapies in solid tumours (DOC 55 kb)
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Neal, J., Sledge, G. Successes, toxicities and challenges in solid tumours. Nat Rev Clin Oncol 11, 627–628 (2014). https://doi.org/10.1038/nrclinonc.2014.171
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DOI: https://doi.org/10.1038/nrclinonc.2014.171
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