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Advanced Hodgkin lymphoma—balancing toxicity and cure

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Cancer medicine frequently balances probability of cure against morbidity of treatment. A recent trial in patients with Hodgkin lymphoma compared two regimens of different intensity and toxicity and examined not only the immediate results, but also the broader algorithm of care, factoring in the effects of salvage treatment and high-dose therapy.

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References

  1. Johnson, P. W. et al. Comparison of ABVD and alternating or hybrid multidrug regimens for the treatment of advanced Hodgkin's lymphoma: results of the United Kingdom Lymphoma Group LY09 Trial (ISRCTN97144519). J. Clin. Oncol. 23, 9208–9218 (2005).

    Article  CAS  Google Scholar 

  2. Hoskin, P. J. et al. Randomized comparison of the Stanford V regimen and ABVD in the treatment of advanced Hodgkin's Lymphoma: United Kingdom National Cancer Research Institute Lymphoma Group Study ISRCTN 64141244. J. Clin. Oncol. 27, 5390–5396 (2009).

    Article  Google Scholar 

  3. Diehl, V. et al. Standard and increased-dose BEACOPP chemotherapy compared with COPP-ABVD for advanced Hodgkin's disease. N. Engl. J. Med. 348, 2386–2395 (2003).

    Article  CAS  Google Scholar 

  4. Engert, A. et al. Escalated-dose BEACOPP in the treatment of patients with advanced-stage Hodgkin's lymphoma: 10 years of follow-up of the GHSG HD9 study. J. Clin. Oncol. 27, 4548–4554 (2009).

    Article  Google Scholar 

  5. Viviani, S. et al. ABVD versus BEACOPP for Hodgkin's lymphoma when high-dose salvage is planned. N. Engl. J. Med. 365, 203–212 (2011).

    Article  CAS  Google Scholar 

  6. Federico, M. et al. ABVD compared with BEACOPP compared with CEC for the initial treatment of patients with advanced Hodgkin's lymphoma: results from the HD2000 Gruppo Italiano per lo Studio dei Linfomi Trial. J. Clin. Oncol. 27, 805–811 (2009).

    Article  Google Scholar 

  7. Aleman, B. M. et al. Involved-field radiotherapy for advanced Hodgkin's lymphoma. N. Engl. J. Med. 348, 2396–2406 (2003).

    Article  Google Scholar 

  8. Johnson, P. W. et al. Consolidation radiotherapy in patients with advanced Hodgkin's lymphoma: survival data from the UKLG LY09 randomized controlled trial (ISRCTN97144519). J. Clin. Oncol. 28, 3352–3359 (2010).

    Article  Google Scholar 

  9. Gallamini, A. et al. Early interim 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography is prognostically superior to international prognostic score in advanced-stage Hodgkin's lymphoma: a report from a joint Italian-Danish study. J. Clin. Oncol. 25, 3746–3752 (2007).

    Article  CAS  Google Scholar 

  10. US National Library of Medicine. ClinicalTrials.gov [online], (2010).

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Correspondence to Peter W. M. Johnson.

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Lim, S., Johnson, P. Advanced Hodgkin lymphoma—balancing toxicity and cure. Nat Rev Clin Oncol 8, 634–636 (2011). https://doi.org/10.1038/nrclinonc.2011.137

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