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Dyslipidaemias in 2017

Atherogenic lipoproteins as treatment targets

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Research on dyslipidaemias in 2017 reaffirmed the central role of reducing the levels of atherogenic apolipoprotein B-containing lipoproteins, predominantly LDL, in preventing ischaemic cardiovascular events. However, whether increasing HDL-cholesterol levels in isolation can reduce cardiovascular risk remains to be determined.

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Figure 1: Overview of lipoprotein metabolism and effects of novel lipid-modulating approaches.

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Authors and Affiliations

  1. Alberico L. Catapano is at the Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy,

    Alberico L. Catapano

  2. IRCCS MultiMedica, Sesto S. Giovanni, Via Milanese 100, 20099 Milan, Italy.,

    Alberico L. Catapano

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  1. Alberico L. Catapano
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Correspondence to Alberico L. Catapano.

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Competing interests

A.L.C. received research funding and honoraria as a speaker or consultant for Aegerion, Amgen, AstraZeneca, Eli Lilly, Genzyme, Mediolanum, Merck, Pfizer, Recordati, Rottapharm, Sanofi-Regeneron, and Sigma-Tau.

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Catapano, A. Atherogenic lipoproteins as treatment targets. Nat Rev Cardiol 15, 75–76 (2018). https://doi.org/10.1038/nrcardio.2017.221

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