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Standardizing animal atherosclerosis studies to improve reproducibility

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Contradictory results in animal atherosclerosis studies might partly explain limited translational efficacy, and also undermine the confidence of funding agencies, politicians, and the public in scientists and their research. A new guideline paper provides recommendations aimed at standardization of animal atherosclerosis studies to improve the reproducibility of this research.

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Figure 1: Advanced atherosclerotic lesion in a hypercholesterolaemic mouse.

References

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Authors and Affiliations

  1. Oliver Soehnlein and Carlos Silvestre-Roig are at the Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich, Pettenkoferstrasse 9, 80336 Munich, Germany; and the German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.,

    Oliver Soehnlein & Carlos Silvestre-Roig

  2. and the German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.,

    Oliver Soehnlein & Carlos Silvestre-Roig

  3. Oliver Soehnlein is also at the Department of Physiology and Pharmacology, Karolinska Institutet, von Eulers Väg 8, 17177 Stockholm, Sweden.,

    Oliver Soehnlein

Authors
  1. Oliver Soehnlein
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  2. Carlos Silvestre-Roig
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Corresponding author

Correspondence to Oliver Soehnlein.

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Competing interests

The authors declare no competing financial interests.

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Soehnlein, O., Silvestre-Roig, C. Standardizing animal atherosclerosis studies to improve reproducibility. Nat Rev Cardiol 14, 574–575 (2017). https://doi.org/10.1038/nrcardio.2017.132

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