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Where do new endothelial cells come from in the injured heart?

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From Nature Reviews Cardiology

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Revascularization of ischaemia-injured myocardium is critical for functional recovery. A new study shows that endothelial cells of neovessels in the injured heart derive from pre-existing endothelial cells. This new finding focuses research on therapeutic strategies to direct the neovasculature to deliver oxygen and nutrients effectively to the ischaemic myocardium.

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Figure 1: Myocardial neovascularization and repair.

References

  1. He, L. et al. Preexisting endothelial cells mediate cardiac neovascularization after injury. J. Clin. Invest. http://dx.doi.org/10.1172/JCI93868 (2017).

  2. Das, S. & Red-Horse, K. Cellular plasticity in cardiovascular development and disease. Dev. Dyn. 246, 328–335 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Tian, X. et al. Vessel formation. De novo formation of a distinct coronary vascular population in neonatal heart. Science 345, 90–94 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Chen, H. I. et al. The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis. Development 141, 4500–4512 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Aghajanian, H. et al. Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor. Nat. Commun. 7, 12038 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Ubil, E. et al. Mesenchymal–endothelial transition contributes to cardiac neovascularization. Nature 514, 585–590 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Pinto, A. R. et al. Revisiting cardiac cellular composition. Circ. Res. 118, 400–409 (2016).

    Article  CAS  PubMed  Google Scholar 

  8. Bergmann, O. et al. Dynamics of cell generation and turnover in the human heart. Cell 161, 1566–1575 (2015).

    Article  CAS  PubMed  Google Scholar 

  9. Zeisberg, E. M. et al. Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat. Med. 13, 952–961 (2007).

    Article  CAS  PubMed  Google Scholar 

  10. Simons, M. & Eichmann, A. Molecular controls of arterial morphogenesis. Circ. Res. 116, 1712–1724 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

The authors acknowledge funding from March of Dimes (Gene Discovery & Translational Grant, 6-FY15-223 to D.M.G.) and NIH (R01HL125815 and R01HL133016 to D.M.G.; R01 EY025979-01 and R01HLI125811 to A.E.).

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Authors and Affiliations

  1. Daniel M. Greif is at the Cardiovascular Research Center and the Departments of Medicine and Genetics, 300 George Street, Yale University School of Medicine, New Haven, Connecticut 06510–3221, USA.,

    Daniel M. Greif

  2. Anne Eichmann is at the Cardiovascular Research Center and the Department of Cellular and Molecular Physiology, 300 George Street, Yale University School of Medicine, New Haven, Connecticut 06510–3221, USA,

    Anne Eichmann

  3. and at INSERM U970, Paris Cardiovascular Research Center, 56 Rue Leblanc, 75015 Paris, France.,

    Anne Eichmann

Authors
  1. Daniel M. Greif
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  2. Anne Eichmann
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Correspondence to Daniel M. Greif or Anne Eichmann.

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The authors declare no competing financial interests.

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Greif, D., Eichmann, A. Where do new endothelial cells come from in the injured heart?. Nat Rev Cardiol 14, 507–508 (2017). https://doi.org/10.1038/nrcardio.2017.121

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