Skip to main content
SpringerLink
Log in

Stem cells

Bone-marrow-derived cells and heart failure—the debate goes on

  • News & Views
  • Published:

From Nature Reviews Cardiology

View current issue Sign up to alerts

The therapeutic efficacy of bone-marrow-derived cells in patients with acute or chronic myocardial infarction has been a matter of intense debate. Three new clinical trials—the Swiss-AMI, CELLWAVE, and C-CURE studies—unfortunately do not resolve the controversy in the field of cell therapy for the damaged heart.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Several cell types have been implemented clinically to promote myocardial regeneration.

References

  1. Sürder, D. et al. Intracoronary injection of bone marrow derived mononuclear cells, early or late after acute myocardial infarction: effects on global left ventricular function four months results of the SWISS-AMI trial. Circulation http://dx.doi.org/10.1161/CIRCULATIONAHA.112.001035.

  2. Assmus, B. et al. Effect of shock wave-facilitated intracoronary cell therapy on LVEF in patients with chronic heart failure: the CELLWAVE randomized clinical trial. JAMA 309, 1622–1631 (2013).

    Article  CAS  Google Scholar 

  3. Bartunek, J. et al. Cardiopoietic stem cell therapy in heart failure. The C-CURE multicentre randomized trial with lineage-specified biologics. J. Am. Coll. Cardiol. http://dx.doi.org/10.1016/j.jacc.2013.02.071.

  4. Orlic, D. et al. Bone marrow cells regenerate infarcted myocardium. Nature 410, 701–705 (2001).

    Article  CAS  Google Scholar 

  5. Jeevanantham, V. et al. Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: a systematic review and meta-analysis. Circulation 126, 551–568 (2012).

    Article  Google Scholar 

  6. Anversa, P., Kajstura, J., Rota, M. & Leri, A. Regenerating new heart with stem cells. J. Clin. Invest. 123, 62–70 (2013).

    Article  CAS  Google Scholar 

  7. Beltrami, A. P. et al. Evidence that human cardiac myocytes divide after myocardial infarction. N. Engl. J. Med. 344, 1750–1757 (2001).

    Article  CAS  Google Scholar 

  8. Hatzistergos, K. E. et al. Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ. Res. 107, 913–922 (2010).

    Article  CAS  Google Scholar 

  9. Bearzi, C. et al. Human cardiac stem cells. Proc. Natl Acad. Sci. USA 104, 14068–14073 (2007).

    Article  CAS  Google Scholar 

  10. Bolli, R. et al. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet 378, 1847–1857 (2011).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Anesthesia and Medicine, and Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, 02115, MA, USA

    Annarosa Leri & Piero Anversa

Authors
  1. Annarosa Leri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Piero Anversa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Piero Anversa.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Leri, A., Anversa, P. Bone-marrow-derived cells and heart failure—the debate goes on. Nat Rev Cardiol 10, 372–373 (2013). https://doi.org/10.1038/nrcardio.2013.81

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrcardio.2013.81

  • Springer Nature Limited

This article is cited by

Search

Navigation