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Polypills for cardiovascular prevention: a step forward?

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The effect of a fixed-dose combination drug strategy ('polypill') on patients' adherence to medication was analysed in a series of 2,004 individuals with, or at high risk of, cardiovascular disease in the UMPIRE study. The polypill improved adherence by >20%, but the reduction in blood-pressure and cholesterol levels was modest.

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Author information

Authors and Affiliations

  1. Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Alamgro 3, Madrid, 28029, Spain

    Ginés Sanz

  2. Cardiovascular Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, PO Box 1030, New York, 10029-6574, NY, USA

    Valentin Fuster

Authors
  1. Ginés Sanz
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  2. Valentin Fuster
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Corresponding author

Correspondence to Valentin Fuster.

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Competing interests

The authors declare no competing interests. G. Sanz and V. Fuster are involved in designing and trialling a polypill with Ferrer Internacional (Barcelona, Spain).

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Sanz, G., Fuster, V. Polypills for cardiovascular prevention: a step forward?. Nat Rev Cardiol 10, 683–684 (2013). https://doi.org/10.1038/nrcardio.2013.157

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