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Coronary artery disease

Platelet activity: an obstacle for successful PCI

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Dual antiplatelet therapy with aspirin and clopidogrel is effective in limiting adverse coronary thromboischemic events in most patients undergoing coronary stenting. However, platelet reactivity to clopidogrel is variable and stent thrombosis can occur suddenly and unexpectedly in up to 3% of patients. Is responsiveness to clopidogrel an indicator of risk of post-treatment thromboischemic events?

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Figure 1: Estimation of residual platelet activity after coronary stenting.

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Authors and Affiliations

  1. Department of Cardiology, University of Tübingen, Germany

    Meinrad Gawaz & Tobias Geisler

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  1. Meinrad Gawaz
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  2. Tobias Geisler
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Correspondence to Tobias Geisler.

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The authors declare no competing financial interests.

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Gawaz, M., Geisler, T. Platelet activity: an obstacle for successful PCI. Nat Rev Cardiol 6, 391–392 (2009). https://doi.org/10.1038/nrcardio.2009.76

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