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Antiplatelet therapy

Ticagrelor in ACS—what does PLATO teach us?

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The novel antiplatelet agent ticagrelor was evaluated against clopidogrel in the PLATO trial of patients with acute coronary syndromes. This article discusses the main findings and importance of this study, including the reduction in mortality associated with ticagrelor therapy.

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Figure 1: Mechanism of action of ticagrelor.

References

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Authors and Affiliations

  1. Veterans Affairs Boston Healthcare System and Brigham and Women's Hospital, Boston, MA, USA

    Deepak L. Bhatt

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  1. Deepak L. Bhatt
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Correspondence to Deepak L. Bhatt.

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Competing interests

D. L. Bhatt has received research grants to his institution for studies in which he served as primary investigator from Bristol-Myers Squibb, Eisai, Ethicon, Heartscape Technologies, Sanofi-Aventis, and The Medicines Company. He has served as a consultant, or as a member of the Advisory Board (honoraria waived or donated for >3 years), for Arena Pharmaceuticals, Astellas, Astra Zeneca, Bayer, Bristol-Myers Squibb, Cardax, Centocor, Daiichi-Sankyo, Eisai, Eli Lilly, GlaxoSmithKline, Johnson & Johnson, Medtronic, Millennium Pharmaceuticals, Molecular Insight Pharmaceuticals, Ortho-McNeil, Otsuka, Paringenix, PDL BioPharma, Philips, Portola Pharmaceuticals, Sanofi-Aventis, Schering-Plough, Takeda, The Medicines Company, and Vertex.

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Bhatt, D. Ticagrelor in ACS—what does PLATO teach us?. Nat Rev Cardiol 6, 737–738 (2009). https://doi.org/10.1038/nrcardio.2009.192

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