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Revisiting tissue specificity of germline cancer predisposing mutations

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Abstract

Heritable germline mutations in major cancer genes generally lead to a restricted pattern of tissue-specific malignancies, yet many of the same mutations frequently occur somatically in a broad range of spontaneous neoplasms affecting different organs. Might this reflect a difference in tumorigenesis in children and adults?

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Acknowledgements

Work in the authors' laboratories was supported by the Giulio D'Angio Endowed Chair at the Children's Hospital of Philadelphia (JMM).

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Authors and Affiliations

  1. The Children's Hospital, 3501 Civic Center Boulevard, Philadelphia, 19104, Philadelphia, USA

    John M. Maris

  2. Division of Population Science, Fox Chase Cancer Centre, 333 Cottman Avenue, Philadelphia, 19111, Philadelphia, USA

    Alfred G. Knudson

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  1. John M. Maris
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  2. Alfred G. Knudson
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Correspondence to John M. Maris.

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The authors declare no competing financial interests.

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Maris, J., Knudson, A. Revisiting tissue specificity of germline cancer predisposing mutations. Nat Rev Cancer 15, 65–66 (2015). https://doi.org/10.1038/nrc3894

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