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Spontaneous regression of metastatic cancer: learning from neuroblastoma

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Abstract

Several interesting biological questions arise when thinking about the heterogeneous presentation of neuroblastoma, especially with regard to the molecular differences between very low- and high-risk disease. Why do some metastatic tumours spontaneously differentiate or regress entirely? Does the presence of disseminated disease always indicate metastases, or might some cases be better considered as multifocal disease?

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References

  1. Cheung, N.-K. V. & Dyer, M. A. Neuroblastoma: developmental biology, cancer genomics and immunotherapy. Nature Rev. Cancer 13, 397–411 (2013).

    Article  CAS  Google Scholar 

  2. Cohn, S. L. et al. The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report. J. Clin. Oncol. 27, 289–297 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Pugh, T. J. et al. The genetic landscape of high-risk neuroblastoma. Nature Genet. 45, 279–284 (2013).

    Article  CAS  Google Scholar 

  4. Molenaar, J. J. et al. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes. Nature 483, 589–593 (2012).

    Article  CAS  Google Scholar 

  5. Sausen, M. et al. Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma. Nature Genet. 45, 12–17 (2013).

    Article  CAS  PubMed  Google Scholar 

  6. Nakagawara, A. et al. Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma. N. Engl. J. Med. 328, 847–854 (1993).

    Article  CAS  PubMed  Google Scholar 

  7. D'Angio, G. J., Evans, A. E. & Koop, C. E. Special pattern of widespread neuroblastoma with a favourable prognosis. Lancet 1, 1046–1049 (1971).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, C3-168, P.O. Box 19024, Seattle, 98109-1024, Washington, USA

    Scott J. Diede

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  1. Scott J. Diede
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Correspondence to Scott J. Diede.

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Diede, S. Spontaneous regression of metastatic cancer: learning from neuroblastoma. Nat Rev Cancer 14, 71–72 (2014). https://doi.org/10.1038/nrc3656

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