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Protein physics

Forever ageing

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Single-molecule techniques have long given us insight into the motion and interactions of individual molecules. But simulations now show that the dynamics inside single proteins is not as simple as we thought — and that proteins are forever changing.

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Figure 1: The simulations of Hu et al.6 measure the relative distance d(t) of two amino acids that are remote to each other in terms of the chemical co-ordinate along the protein backbone.

References

  1. Zhou, H. X., Rivas, G. & Minton, A. P. Annu. Rev. Biophys. 37, 375–397 (2008).

    Article  Google Scholar 

  2. McGuffee, S. R. & Elcock, A. H. PLoS Comput. Biol. 6, e1000694 (2010).

    Article  ADS  Google Scholar 

  3. Barkai, E., Garini, Y. & Metzler, R. Phys. Today 65 (8), 29–35 (2012).

    Article  Google Scholar 

  4. Höfling, F. & Franosch, T. Rep. Prog. Phys. 76, 046602 (2013).

    Article  ADS  Google Scholar 

  5. Di Rienzo, C., Piazza, V., Gratton, E., Beltram, F. & Cardarelli, F. Nature Commun. 5, 5891 (2014).

    Article  ADS  Google Scholar 

  6. Hu, X. et al. Nature Phys. http://dx.doi.org/10.1038/nphys3553 (2015).

  7. Austin, R. H. et al. Biochemistry 14, 5355–5373 (1975).

    Article  Google Scholar 

  8. Frauenfelder, H., Sligar, S. G. & Wolynes, P. G. Science 254, 1598–1603 (1988).

    Article  ADS  Google Scholar 

  9. Yang, H. et al. Science 302, 262–266 (2003).

    Article  ADS  Google Scholar 

  10. Min, W., Luo, G., Cherayil, B. J., Kou, S. C. & Xie, X. S. Phys. Rev. Lett. 94, 198302 (2005).

    Article  ADS  Google Scholar 

  11. Schulz, J. H. P., Barkai, E. & Metzler, R. Phys. Rev. X 4, 011028 (2014).

    Google Scholar 

  12. Burov, S., Metzler, R. & Barkai, E. Proc. Natl Acad. Sci. USA 107, 13228–13233 (2010).

    Article  ADS  MathSciNet  Google Scholar 

  13. Monthus, C. & Bouchaud, J. P. J. Phys. A 29, 3847–3869 (1996).

    Article  ADS  Google Scholar 

Download references

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Correspondence to Ralf Metzler.

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Metzler, R. Forever ageing. Nature Phys 12, 113–114 (2016). https://doi.org/10.1038/nphys3585

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