Conventional atomic force microscopy probes only the surface of specimens. A related technique called scanning near-field ultrasonic holography can now image nanoparticles buried below the surfaces of cells, which could prove useful in nanotoxicology.
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Sahin, O. Scanning below the cell surface. Nature Nanotech 3, 461–462 (2008). https://doi.org/10.1038/nnano.2008.222
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DOI: https://doi.org/10.1038/nnano.2008.222
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